Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 known ✓ | P35354 | 1/20 | 0.38 |
| ▸ | THRA | P10827 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | TNNC1 | P63316 | 5/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 4/20 | 0.38 |
| ▸ | S1PR3 | Q99500 | 3/20 | 0.38 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.38 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.38 |
| ▸ | SGPL1 | O95470 | 1/20 | 0.38 |
| ▸ | GPR183 | P32249 | 1/20 | 0.38 |
| ▸ | CERS2 | Q96G23 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | SPHK2 | Q9NRA0 | 2/20 | 0.36 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.36 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.36 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.35 |
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tromethamine SCHEMBL11416037 | 0.95 | THRA (0.49) | THRATHRBTNNC1S1PR1S1PR3 | |
| Tromethamine SCHEMBL7621218 | 0.95 | THRA (0.49) | THRATHRBTNNC1S1PR1S1PR3 | |
| Tromethamine SCHEMBL441429 | 0.95 | THRA (0.49) | THRATHRBTNNC1S1PR1S1PR3 | |
| SCHEMBL795569 | 0.88 | THRA (0.50) | THRATHRBALOX5PTGS2LIPG | |
| SCHEMBL30617325 | 0.88 | THRA (0.50) | THRATHRBALOX5PTGS2LIPG | |
| Tromethamine SCHEMBL6059851 | 0.88 | PTGS2 (0.39) | THRATHRBTNNC1S1PR1S1PR3 | |
| Tromethamine SCHEMBL6763980 | 0.85 | L3MBTL1 (0.39) | THRBS1PR1S1PR3 | |
| SCHEMBL31012117 | 0.84 | THRA (0.56) | THRATHRBALOX5PTGS2LIPG | |
| SCHEMBL163337 | 0.84 | THRA (0.56) | THRATHRBALOX5PTGS2LIPG | |
| Tromethamine SCHEMBL2776786 | 0.83 | S1PR1 (0.43) | THRATHRBTNNC1S1PR1S1PR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020137827-A1 | Polycarbonate resin for optical disk substrate and optical disk substrate | IDEMITSU KOSAN CO. LTD. (JP) | 2002-09-26 | — | — | US | disclosed |