Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 16/20 | 0.39 |
| ▸ | JAK2 | O60674 | 13/20 | 0.39 |
| ▸ | JAK1 | P23458 | 10/20 | 0.39 |
| ▸ | TYK2 | P29597 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20183292 | 0.80 | ALDH1A1 (0.42) | JAK3JAK2JAK1TYK2ALDH1A1 | |
| SCHEMBL18525632 | 0.78 | CHRM2 (0.44) | JAK3JAK2JAK1TYK2ALDH1A1 | |
| SCHEMBL13724137 | 0.76 | JAK3 (0.44) | JAK3JAK2JAK1TYK2ALDH1A1 | |
| SCHEMBL14426034 | 0.76 | ALDH1A1 (0.63) | ALDH1A1MEN1MAPTKMT2ALMNA | |
| SCHEMBL22620113 | 0.76 | JAK3 (0.44) | JAK3JAK2JAK1TYK2ALDH1A1 | |
| SCHEMBL12957767 | 0.76 | ALDH1A1 (0.63) | ALDH1A1MEN1MAPTKMT2ALMNA | |
| SCHEMBL14644693 | 0.76 | ALDH1A1 (0.63) | ALDH1A1MEN1MAPTKMT2ALMNA | |
| SCHEMBL20590846 | 0.75 | LMNA (0.33) | ALDH1A1MEN1MAPTKMT2ALMNA | |
| SCHEMBL22719629 | 0.75 | LMNA (0.33) | ALDH1A1MEN1MAPTKMT2ALMNA | |
| SCHEMBL22370793 | 0.75 | JAK2 (0.47) | JAK3JAK2JAK1TYK2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020034987-A1 | PRODRUG CONTAINING GLUCURONIDE DERIVATIVE OF JAK INHIBITOR, PREPARATION METHOD THEREFOR, AND USES THEREOF | 江苏豪森药业集团有限公司 | 2020-02-20 | — | — | WO | disclosed |