Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 2/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | RORC | P51449 | 18/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 11/20 | 0.37 |
| ▸ | IL17A | Q16552 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21732235 | 0.89 | RORC (0.50) | RORCCYP2D6IL17AKCNH2 | |
| SCHEMBL21732119 | 0.88 | NTRK1 (0.41) | NTRK1JAK2 | |
| SCHEMBL21732225 | 0.87 | RORC (0.37) | NTRK1JAK2RORCCYP2D6IL17A | |
| SCHEMBL21732266 | 0.82 | RORC (0.38) | NTRK1JAK2RORCCYP2D6IL17A | |
| SCHEMBL21732220 | 0.81 | NTRK1 (0.44) | NTRK1JAK2 | |
| SCHEMBL21732296 | 0.80 | RORC (0.37) | NTRK1JAK2RORCCYP2D6IL17A | |
| SCHEMBL21732208 | 0.80 | RORC (0.39) | NTRK1RORCCYP2D6IL17AKCNH2 | |
| SCHEMBL21732214 | 0.80 | RORC (0.36) | NTRK1RORCCYP2D6IL17AKCNH2 | |
| SCHEMBL21732294 | 0.77 | RORC (0.42) | RORCCYP2D6IL17AKCNH2 | |
| SCHEMBL21732084 | 0.77 | RORC (0.44) | RORCCYP2D6IL17AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020035557-A1 | NOVEL HETEROAROMATIC MODULATORS OF THE RETINOID-RELATED ORPHAN RECEPTOR GAMMA | LEO PHARMA A/S (DK) | 2020-02-20 | — | — | WO | disclosed |