Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.50 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.45 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.43 |
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | TACR1 | P25103 | 1/20 | 0.43 |
| ▸ | BCHE | P06276 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5104857 | 0.77 | HSP90AA1 (0.59) | HSP90AA1EPHX2P2RX7TACR1NPC1 | |
| SCHEMBL16510056 | 0.76 | POLB (0.60) | HSP90AA1TSHRP2RX7TACR1NPC1 | |
| SCHEMBL14359179 | 0.75 | HSP90AA1 (0.56) | HSP90AA1P2RX7TACR1NPC1RAB9A | |
| SCHEMBL13485746 | 0.74 | HSP90AA1 (0.55) | HSP90AA1TSHRP2RX7TACR1NPC1 | |
| SCHEMBL28848822 | 0.73 | RIPK1 (0.64) | HSP90AA1P2RX7TACR1NPC1RAB9A | |
| SCHEMBL18390882 | 0.72 | KCNH2 (0.62) | TSHRNPC1RAB9APOLBCHRM3 | |
| SCHEMBL13485747 | 0.72 | HSP90AA1 (0.54) | HSP90AA1P2RX7TACR1NPC1RAB9A | |
| SCHEMBL25694235 | 0.72 | RIPK1 (0.67) | RIPK1 | |
| SCHEMBL16268556 | 0.71 | HSP90AA1 (0.53) | HSP90AA1P2RX7TACR1NPC1RAB9A | |
| SCHEMBL27906099 | 0.71 | P2RX7 (0.66) | HSP90AA1EPHX2TSHRCHRM1P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200055860-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRAZINE COMPOUNDS AS RET KINASE INHIBITORS | ARRAY BIOPHARMA INC | 2020-02-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200055860-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRAZINE COMPOUNDS AS RET KINASE INHIBITORS | RET, BRAF, ROR1 | HSP90AA1 4565/4885EPHX2 2422/4885TSHR 1588/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.