SCHEMBL2173486

SCHEMBL2173486

C[C@@]1(c2cccnc2)CCCN1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 6/20 0.43
CHRNA4 P43681 6/20 0.43
CHRNA7 P36544 3/20 0.43
CHRNA1 P02708 1/20 0.43
CHRNG P07510 1/20 0.43
CHRNB1 P11230 1/20 0.43
CHRNB4 P30926 1/20 0.43
CHRNA3 P32297 1/20 0.43
CHRND Q07001 1/20 0.43
PARP1 P09874 4/20 0.36
PARP2 Q9UGN5 3/20 0.36
TNKS O95271 1/20 0.36
PARP14 Q460N5 1/20 0.36
PARP10 Q53GL7 1/20 0.36
PARP12 Q9H0J9 1/20 0.36
TNKS2 Q9H2K2 1/20 0.36
PARP4 Q9UKK3 1/20 0.36
PARP3 Q9Y6F1 1/20 0.36
KDM4E B2RXH2 1/20 0.35
ALDH1A1 P00352 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16198316 1.00 CHRNB2 (0.43) CHRNB2CHRNA4CHRNA7CHRNA1CHRNG
SCHEMBL155505 1.00 CHRNB2 (0.43) CHRNB2CHRNA4CHRNA7CHRNA1CHRNG
SCHEMBL11285777 0.95 CHRNB2 (0.40) CHRNB2CHRNA4CHRNA7CHRNA1CHRNG
SCHEMBL246083 0.91 CHRNB2 (0.43) CHRNB2CHRNA4CHRNA7CHRNA1CHRNG
SCHEMBL15995119 0.78 OPRM1 (0.42) PARP1PARP2TNKSPARP14PARP10
SCHEMBL21312268 0.78 OPRM1 (0.42) PARP1PARP2TNKSPARP14PARP10
SCHEMBL15995122 0.78 OPRM1 (0.42) PARP1PARP2TNKSPARP14PARP10
SCHEMBL32681150 0.77 PARP1 (0.33) PARP1PARP2TNKSPARP14PARP10
SCHEMBL11240260 0.73 VNN1 (0.43) CHRNB2CHRNA4CHRNA7CHRNA1CHRNG
SCHEMBL10984276 0.73 VNN1 (0.43) CHRNB2CHRNA4CHRNA7CHRNA1CHRNG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2830589-A1 NICOTINE FORMULATION NICOCCINO AB (SE) 2015-02-04 EP disclosed
WO-2014174505-A2 A PROCESS FOR THE PREPARATION OF NICOTINE COMPRISING THE ENZYMATIC REDUCTION OF 4- (METHYLAMINO) -1- (PYRIDIN-3- YL) BUTAN-1-ONE PERRIGO API LTD. (IL) 2014-10-30 WO disclosed
WO-2014134221-A1 COMPOSITIONS AND METHODS FOR TREATMENT IN PARKINSON'S DISEASE PATIENTS AZHIR ARI (US) 2014-09-04 WO disclosed
WO-2013143891-A1 NICOTINE FORMULATION UPPSALAGRUPPEN MEDICAL AB (SE) 2013-10-03 WO disclosed
EP-2346528-A1 NICOTINE IMMUNONANOTHERAPEUTICS Massachusetts Institute of Technology (US) 2011-07-27 EP disclosed
WO-2010042866-A1 NICOTINE IMMUNONANOTHERAPEUTICS MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 2010-04-15 WO disclosed