Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.30 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.30 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.30 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.30 |
| ▸ | SELE | P16581 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21735010 | 0.93 | PPARG (0.35) | PCSK9THRBS1PR4S1PR1S1PR5 | |
| SCHEMBL21735476 | 0.91 | THRB (0.38) | PCSK9THRB | |
| SCHEMBL21735478 | 0.91 | S1PR1 (0.33) | PCSK9THRBS1PR4S1PR1S1PR5 | |
| SCHEMBL21735795 | 0.91 | PCSK9 (0.32) | PCSK9S1PR1 | |
| SCHEMBL21735475 | 0.90 | THRB (0.32) | PCSK9THRBS1PR4S1PR1S1PR5 | |
| SCHEMBL26291717 | 0.89 | PCSK9 (0.34) | PCSK9THRBS1PR1ICAM1SELE | |
| SCHEMBL21735266 | 0.89 | PCSK9 (0.33) | PCSK9THRBS1PR1 | |
| SCHEMBL21735301 | 0.88 | PCSK9 (0.32) | PCSK9 | |
| SCHEMBL26291712 | 0.86 | PCSK9 (0.36) | PCSK9THRBS1PR1 | |
| SCHEMBL21735428 | 0.86 | PCSK9 (0.33) | PCSK9THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11014901-B2 | Hydrophobic compounds for optically active devices | MERCK PATENT GMBH (DE) | 2021-05-25 | — | — | US | disclosed |
| EP-3583091-B1 | HYDROPHOBIC COMPOUNDS FOR OPTICALLY ACTIVE DEVICES | MERCK PATENT GMBH (DE) | 2020-11-04 | — | — | EP | disclosed |
| US-20200055833-A1 | HYDROPHOBIC COMPOUNDS FOR OPTICALLY ACTIVE DEVICES | MERCK PATENT GMBH (DE) | 2020-02-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200055833-A1 | HYDROPHOBIC COMPOUNDS FOR OPTICALLY ACTIVE DEVICES | UACA, CRYZ, TRPA1 | PCSK9 3356/4885THRB 3289/4885S1PR4 3683/4885 |
| US-11014901-B2 | Hydrophobic compounds for optically active devices | UACA, CRYZ, TRPA1 | PCSK9 3356/4885THRB 3289/4885S1PR4 3683/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.