Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK2 | Q9HBH9 | 8/20 | 0.40 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.32 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.32 |
| ▸ | LTA4H | P09960 | 1/20 | 0.32 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25818492 | 0.86 | MKNK2 (0.40) | MKNK2MKNK1CYP1A2CYP3A4HSD17B10 | |
| SCHEMBL13195335 | 0.83 | MKNK2 (0.40) | MKNK2MKNK1CYP1A2MTNR1AEGFR | |
| SCHEMBL24110604 | 0.79 | HTR2C (0.47) | MKNK2MTNR1AEGFR | |
| SCHEMBL5068124 | 0.79 | MKNK2 (0.42) | MKNK2MKNK1CYP1A2CYP3A4HSD17B10 | |
| SCHEMBL28212561 | 0.78 | CYP1A2 (0.47) | CYP1A2CYP3A4HSD17B10USP2ALDH1A1 | |
| SCHEMBL28212072 | 0.75 | CYP1A2 (0.45) | CYP1A2CYP3A4HSD17B10USP2ALDH1A1 | |
| SCHEMBL18926936 | 0.75 | MKNK2 (0.39) | MKNK2MKNK1PRMT5WDR77RPS6KA3 | |
| SCHEMBL8817640 | 0.75 | MKNK2 (0.39) | MKNK2MKNK1HSD17B10ALDH1A1EGFR | |
| SCHEMBL27845067 | 0.75 | RPS6KA3 (0.36) | RPS6KA3KMT2A | |
| SCHEMBL15833690 | 0.74 | MTNR1A (0.36) | MKNK2MKNK1ALDH1A1MTNR1APRMT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102227422-A | Heterocyclic jak kinase inhibitors | ASTRAZENECA AB | 2011-10-26 | — | — | CN | claimed |
| US-20110201628-A1 | HETEROCYCLIC JAK KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2011-08-18 | — | — | US | claimed |
| EP-2346859-A1 | HETEROCYCLIC JAK KINASE INHIBITORS | AstraZeneca AB (SE) | 2011-07-27 | — | — | EP | claimed |
| WO-2010038060-A1 | HETEROCYCLIC JAK KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2010-04-08 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110201628-A1 | HETEROCYCLIC JAK KINASE INHIBITORS | JAK2, JAK1, JAK3 | MKNK2 164/4885MKNK1 174/4885CYP1A2 1019/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.