Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 9/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2171124 | 0.73 | PGR (0.41) | TP53THRBKMT2ALMNAMAPT | |
| SCHEMBL2173433 | 0.71 | NR1H4 (0.48) | TP53KMT2ALMNAMAPTMEN1 | |
| SCHEMBL2171158 | 0.68 | TP53 (0.43) | TP53THRBKMT2AMAPTMEN1 | |
| SCHEMBL2172075 | 0.68 | KDM4E (0.42) | TP53THRBKMT2ALMNAMAPT | |
| SCHEMBL2567579 | 0.66 | KMT2A (0.63) | TP53KMT2ALMNAMAPTMEN1 | |
| SCHEMBL2173102 | 0.62 | KDM4E (0.42) | TP53THRBKMT2ALMNAMAPT | |
| SCHEMBL3515824 | 0.57 | MAPT (0.42) | TP53KMT2AMAPTMEN1ALDH1A1 | |
| SCHEMBL12677919 | 0.55 | HPGD (0.47) | KMT2ALMNAMAPTMEN1ALDH1A1 | |
| SCHEMBL12601746 | 0.54 | ALDH1A1 (0.54) | TP53KMT2ALMNAMAPTMEN1 | |
| SCHEMBL4659776 | 0.54 | KMT2A (0.54) | TP53KMT2ALMNAMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2346832-A1 | TRICYCLIC COMPOUNDS AS GLUTAMATE RECEPTOR MODULATORS | Glaxo Group Limited (GB) | 2011-07-27 | — | — | EP | claimed |
| WO-2010049366-A1 | TRICYCLIC COMPOUNDS AS GLUTAMATE RECEPTOR MODULATORS | GLAXO GROUP LIMITED (GB) | 2010-05-06 | — | — | WO | claimed |