Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PYGL | P06737 | 8/20 | 0.47 |
| ▸ | PYGM | P11217 | 6/20 | 0.47 |
| ▸ | F11 | P03951 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 6/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22051571 | 0.83 | CREBBP (0.46) | F11GAAMAPTCREBBPBRD4 | |
| SCHEMBL21739487 | 0.80 | TAS1R3 (0.40) | F11CREBBPBRD4 | |
| SCHEMBL21739515 | 0.77 | TAS1R3 (0.51) | MAPT | |
| SCHEMBL14641138 | 0.77 | PYGL (0.57) | PYGLPYGMF11GAAMAPT | |
| SCHEMBL25329367 | 0.76 | PYGL (0.64) | PYGLPYGMGAAMAPTCREBBP | |
| SCHEMBL15541576 | 0.76 | PYGL (0.64) | PYGLPYGMGAAMAPTCREBBP | |
| SCHEMBL29900499 | 0.76 | PYGL (0.64) | PYGLPYGMGAAMAPTCREBBP | |
| SCHEMBL21739369 | 0.76 | TAS1R3 (0.61) | MAPT | |
| SCHEMBL13891430 | 0.75 | PYGL (0.50) | PYGLPYGMF11GAAMAPT | |
| SCHEMBL2837105 | 0.75 | PYGL (0.60) | PYGLPYGMF11CREBBPBRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020112872-A1 | METHODS OF TREATING WHSC1-OVEREXPRESSING CANCERS BY INHIBITING SETD2 | Epizyme, Inc. (US) | 2020-06-04 | — | — | WO | disclosed |
| WO-2020037079-A1 | SUBSTITUTED INDOLES AND METHODS OF USE THEREOF | Epizyme, Inc. (US) | 2020-02-20 | — | — | WO | disclosed |