Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | KDM5A | P29375 | 2/20 | 0.34 |
| ▸ | LIPE | Q05469 | 1/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.32 |
| ▸ | TP53 | P04637 | 2/20 | 0.31 |
| ▸ | PRKAA2 | P54646 | 2/20 | 0.31 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.31 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.31 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.31 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.31 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.31 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.30 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2174025 | 0.90 | CHRM2 (0.41) | CHRM2KDM5ALIPEMCHR1EPHX2 | |
| SCHEMBL5669978 | 0.79 | CHRM2 (0.43) | CHRM2LIPEMCHR1TP53SMN1; SMN2 | |
| SCHEMBL2174258 | 0.71 | MCHR1 (0.40) | MCHR1 | |
| SCHEMBL5668886 | 0.71 | KMT2A (0.41) | MCHR1EPHX2 | |
| SCHEMBL2173319 | 0.70 | MCHR1 (0.40) | MCHR1 | |
| SCHEMBL4387610 | 0.69 | KDM4E (0.42) | CHRM2MCHR1EPHX2GAASMN1; SMN2 | |
| SCHEMBL4389385 | 0.69 | TAOK1 (0.43) | MCHR1 | |
| SCHEMBL4392436 | 0.69 | POLB (0.53) | CHRM2MCHR1EPHX2PRKAA2PRKAB2 | |
| SCHEMBL5668976 | 0.68 | LMNA (0.43) | MCHR1EPHX2SMN1; SMN2LMNA | |
| SCHEMBL5668246 | 0.67 | L3MBTL1 (0.49) | GAALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7973061-B2 | Anaplastic lymphoma kinase modulators and methods of use | EXELIXIS, INC. (US) | 2011-07-05 | — | — | US | claimed |