Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | KCNQ3 | O43525 | 6/20 | 0.38 |
| ▸ | KCNQ2 | O43526 | 6/20 | 0.38 |
| ▸ | KCNE1 | P15382 | 5/20 | 0.38 |
| ▸ | KCNQ1 | P51787 | 5/20 | 0.38 |
| ▸ | KCNQ5 | Q9NR82 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 2/20 | 0.35 |
| ▸ | CES2 | O00748 | 1/20 | 0.34 |
| ▸ | CES1 | P23141 | 1/20 | 0.34 |
| ▸ | CA5A | P35218 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31161376 | 1.00 | KEAP1 (0.39) | KEAP1NFE2L2TDP1KCNQ3KCNQ2 | |
| SCHEMBL31701904 | 0.82 | KEAP1 (0.48) | KEAP1NFE2L2TDP1KCNQ3KCNQ2 | |
| SCHEMBL487403 | 0.82 | KEAP1 (0.48) | KEAP1NFE2L2TDP1KCNQ3KCNQ2 | |
| SCHEMBL31700706 | 0.80 | ALPL (0.38) | KEAP1NFE2L2TDP1KCNQ3KCNQ2 | |
| SCHEMBL21962115 | 0.80 | ALPL (0.38) | KEAP1NFE2L2TDP1KCNQ3KCNQ2 | |
| SCHEMBL990912 | 0.80 | MAPK1 (0.46) | TDP1KCNQ3KCNQ2KCNE1KCNQ1 | |
| SCHEMBL30821487 | 0.80 | MAPK1 (0.46) | TDP1KCNQ3KCNQ2KCNE1KCNQ1 | |
| SCHEMBL2421365 | 0.80 | KMT2A (0.51) | TDP1ALDH1A1MAPK1MEN1KMT2A | |
| SCHEMBL15043882 | 0.78 | CA5A (0.40) | ALDH1A1MAPK1MEN1KMT2ARXFP1 | |
| SCHEMBL13859498 | 0.78 | KMT2A (0.40) | TDP1KCNQ3KCNQ2ALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260125400-A1 | TYK2 DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS INC (US) | 2026-05-07 | — | — | US | disclosed |
| WO-2024220937-A2 | TYK2 DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2024-10-24 | — | — | WO | disclosed |
| WO-2020035065-A1 | PYRAZOLE DERIVATIVE AS RET INHIBITOR | 南京明德新药研发有限公司 | 2020-02-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260125400-A1 | TYK2 DEGRADERS AND USES THEREOF | TYK2, CSNK2A1, CSNK2A2 | KEAP1 1795/4885NFE2L2 694/4885TDP1 1302/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.