Sugi Predict

Sugi Predict / Compounds / SCHEMBL487403

SCHEMBL487403

SCHEMBL487403

O=C(O)c1cnc(Cl)c(F)c1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KEAP1 Q14145 1/20 0.48
▸ NFE2L2 Q16236 1/20 0.48
▸ HCAR2 Q8TDS4 4/20 0.47
▸ NAPRT Q6XQN6 1/20 0.47
▸ MGAM O43451 1/20 0.42
▸ P4HA1 P13674 2/20 0.41
▸ P4HTM Q9NXG6 2/20 0.41
▸ LDHA P00338 3/20 0.41
▸ KDM4E B2RXH2 3/20 0.40
▸ ASPH Q12797 1/20 0.40
▸ KDM8 Q8N371 1/20 0.40
▸ TPMT P51580 1/20 0.40
▸ MIF P14174 1/20 0.39
▸ VNN1 O95497 1/20 0.39
▸ TDP1 Q9NUW8 1/20 0.39
▸ ALDH1A1 P00352 2/20 0.38
▸ GABRP O00591 1/20 0.38
▸ GABRD O14764 1/20 0.38
▸ GABRA1 P14867 1/20 0.38
▸ GABRB1 P18505 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31701904 1.00 KEAP1 (0.48) KEAP1NFE2L2HCAR2NAPRTMGAM
SCHEMBL21744576 0.82 KEAP1 (0.39) KEAP1NFE2L2TDP1ALDH1A1MEN1
SCHEMBL31161376 0.82 KEAP1 (0.39) KEAP1NFE2L2TDP1ALDH1A1MEN1
SCHEMBL11188300 0.80 HCAR2 (0.47) HCAR2NAPRTMGAMP4HA1P4HTM
SCHEMBL30721127 0.79 HCAR2 (0.50) HCAR2NAPRTMGAMP4HA1P4HTM
SCHEMBL898595 0.79 HCAR2 (0.50) HCAR2NAPRTMGAMP4HA1P4HTM
SCHEMBL29365646 0.79 HCAR2 (0.50) HCAR2NAPRTMGAMP4HA1P4HTM
SCHEMBL232290 0.79 HCAR2 (0.50) HCAR2NAPRTMGAMP4HA1P4HTM
SCHEMBL10662404 0.79 KEAP1 (0.38) KEAP1NFE2L2NAPRTLDHAKDM4E
SCHEMBL10501900 0.79 KEAP1 (0.38) KEAP1NFE2L2NAPRTKDM4EASPH

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 126 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2026101924-A1 KRAS MODULATORS ALTEROME THERAPEUTICS, INC. (US) 2026-05-15 — — WO disclosed
US-12600696-B2 Aromatic compounds Xeniopro GmbH (DE) 2026-04-14 — — US disclosed
US-20260085064-A1 SUBSTITUTED BENZOFURANYL AND BENZOXAZOLYL COMPOUNDS AND USES THEREOF KARYOPHARM THERAPEUTICS INC (US) 2026-03-26 — — US disclosed
EP-4651907-A1 DRUG CONJUGATES AND METHODS OF PREPARING AND USING THE SAME Adcentrx Therapeutics Inc. (US) 2025-11-26 — — EP disclosed
WO-2025202864-A1 ENT1 INHIBITORS IN COMBINATION WITH ONCOLYTIC VIRUSES AND THEIR USE IN THE TREATMENT OF CANCER iTeos Belgium SA (BE) 2025-10-02 — — WO disclosed
US-20250304603-A1 OXABOROLE ESTERS AND USES THEREOF ANACOR PHARMACEUTICALS INC (US) 2025-10-02 — — US disclosed
US-12331040-B2 Substituted benzofuranyl and benzoxazolyl compounds and uses thereof Karyopharm Therapeutics Inc. (US) 2025-06-17 — — US disclosed
WO-2025104613-A1 ENT1 INHIBITORS IN COMBINATION WITH CHECKPOINT INHIBITORS iTeos Belgium SA (BE) 2025-05-22 — — WO disclosed
US-20250129044-A1 PYRIDINYL DERIVATIVES AS SODIUM CHANNEL ACTIVATORS XENON PHARMACEUTICALS INC. (CA) 2025-04-24 — — US disclosed
CN-119823097-A PHD inhibitor compounds, compositions and uses 阿克比治疗有限公司 2025-04-15 — — CN disclosed
US-20090181947-A1 BICYCLIC ENAMINO(THIO)CARBONYL COMPOUNDS BAYER CROPSCIENCE AG (DE) 2009-07-16 — — US disclosed
EP-2021344-A1 BICYCLIC ENAMINO(THIO)CARBONYL COMPOUNDS Bayer CropScience AG (DE) 2009-02-11 — — EP disclosed
EP-2004606-A1 SUBSTITUTED ENAMINOCARBONYL COMPOUNDS Bayer CropScience AG (DE) 2008-12-24 — — EP disclosed
EP-2004636-A1 SUBSTITUTED ENAMINOCARBONYL COMPOUNDS USED AS INSECTICIDES Bayer CropScience AG (DE) 2008-12-24 — — EP disclosed
WO-2007115643-A1 SUBSTITUTED ENAMINOCARBONYL COMPOUNDS BAYER CROPSCIENCE AG (DE) 2007-10-18 — — WO disclosed
WO-2007115647-A1 BICYCLIC ENAMINO(THIO)CARBONYL COMPOUNDS BAYER CROPSCIENCE AG (DE) 2007-10-18 — — WO disclosed
WO-2007115646-A1 SUBSTITUTED ENAMINOCARBONYL COMPOUNDS USED AS INSECTICIDES BAYER CROPSCIENCE AG (DE) 2007-10-18 — — WO disclosed
US-4393212-A ADRENERGIC BLOCKING AGENTS MERCK & CO., INC. (US) 1983-07-12 — — US disclosed
US-4294969-A COUPLING N-BROMOSUCCINIMIDE AND A 2-BROMOPYRIDINE MERCK & CO., INC. (US) 1981-10-13 — — US disclosed
US-4279913-A ANTIARRYTHMIA, HYPOTENSIVE MERCK & CO., INC. (US) 1981-07-21 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090181947-A1 BICYCLIC ENAMINO(THIO)CARBONYL COMPOUNDS TARS2, TBCA, DDT KEAP1 37/4885NFE2L2 942/4885HCAR2 4477/4885
US-20250304603-A1 OXABOROLE ESTERS AND USES THEREOF OXA1L, HSD17B12, OXER1 KEAP1 923/4885NFE2L2 1889/4885HCAR2 1200/4885
US-20250129044-A1 PYRIDINYL DERIVATIVES AS SODIUM CHANNEL ACTIVATORS SCN1B, SCN1A, SCN2B KEAP1 3774/4885NFE2L2 3701/4885HCAR2 786/4885
US-12331040-B2 Substituted benzofuranyl and benzoxazolyl compounds and uses thereof BCL6, MALT1, BTK KEAP1 947/4885NFE2L2 924/4885HCAR2 3607/4885
US-12600696-B2 Aromatic compounds CCR1, CCRL2, AHR KEAP1 317/4885NFE2L2 821/4885HCAR2 278/4885
US-20260085064-A1 SUBSTITUTED BENZOFURANYL AND BENZOXAZOLYL COMPOUNDS AND USES THEREOF BCL6, MALT1, BCL6B KEAP1 1121/4885NFE2L2 1108/4885HCAR2 1785/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.