Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.38 |
| ▸ | HTR2C | P28335 | 2/20 | 0.38 |
| ▸ | HTR2B | P41595 | 2/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 13/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 9/20 | 0.32 |
| ▸ | PIK3R1 | P27986 | 7/20 | 0.32 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.32 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.32 |
| ▸ | PRKDC | P78527 | 1/20 | 0.32 |
| ▸ | RPTOR | Q8N122 | 8/20 | 0.32 |
| ▸ | MLST8 | Q9BVC4 | 8/20 | 0.32 |
| ▸ | RICTOR | Q6R327 | 7/20 | 0.32 |
| ▸ | MAPKAP1 | Q9BPZ7 | 7/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21745502 | 1.00 | HTR2A (0.38) | HTR2AHTR2CHTR2BPDE4AMTOR | |
| SCHEMBL21745108 | 1.00 | HTR2A (0.38) | HTR2AHTR2CHTR2BPDE4AMTOR | |
| SCHEMBL21762803 | 0.82 | HTR2A (0.47) | HTR2AHTR2CHTR2B | |
| SCHEMBL21762403 | 0.82 | HTR2A (0.47) | HTR2AHTR2CHTR2B | |
| SCHEMBL21762783 | 0.80 | HTR2A (0.45) | HTR2AHTR2CHTR2B | |
| SCHEMBL21745068 | 0.79 | HTR2A (0.44) | HTR2AHTR2CHTR2BCYP1A2CYP2C9 | |
| SCHEMBL21745496 | 0.79 | HTR2A (0.44) | HTR2AHTR2CHTR2BCYP1A2CYP2C9 | |
| SCHEMBL21745067 | 0.79 | HTR2A (0.44) | HTR2AHTR2CHTR2BCYP1A2CYP2C9 | |
| SCHEMBL21745081 | 0.78 | MTOR (0.33) | PDE4AMTORPIK3CAPIK3R1PIK3C3 | |
| SCHEMBL21745500 | 0.72 | HTR2A (0.36) | HTR2AHTR2CHTR2BPDE4AMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10947252-B2 | Inhibitors of KEAP1-Nrf2 protein-protein interaction | JANSSEN PHARMACEUTICA NV (BE) | 2021-03-16 | — | — | US | disclosed |
| US-20200055874-A1 | INHIBITORS OF KEAP1-Nrf2 PROTEIN-PROTEIN INTERACTION | JANSSEN PHARMACEUTICA NV (BE) | 2020-02-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200055874-A1 | INHIBITORS OF KEAP1-Nrf2 PROTEIN-PROTEIN INTERACTION | KEAP1, NFE2L2, HMOX1 | HTR2A 3969/4885HTR2C 4273/4885HTR2B 4303/4885 |
| US-10947252-B2 | Inhibitors of KEAP1-Nrf2 protein-protein interaction | KEAP1, NFE2L2, HMOX1 | HTR2A 3969/4885HTR2C 4273/4885HTR2B 4303/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.