Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.56 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.56 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.56 |
| ▸ | FFAR3 | O14843 | 2/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.53 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.50 |
| ▸ | PHF8 | Q9UPP1 | 3/20 | 0.46 |
| ▸ | KDM2A | Q9Y2K7 | 3/20 | 0.46 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.46 |
| ▸ | KDM6B | O15054 | 1/20 | 0.44 |
| ▸ | KDM5C | P41229 | 1/20 | 0.44 |
| ▸ | KDM7A | Q6ZMT4 | 1/20 | 0.44 |
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.43 |
| ▸ | PPARG | P37231 | 6/20 | 0.43 |
| ▸ | PPARD | Q03181 | 6/20 | 0.43 |
| ▸ | PPARA | Q07869 | 6/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinic Acid SCHEMBL5874898 | 1.00 | LMNA (0.56) | LMNAEGLN1ALKBH5SUCNR1FFAR3 | |
| Succinic Acid SCHEMBL7441621 | 0.97 | LMNA (0.53) | LMNAEGLN1ALKBH5SUCNR1FFAR3 | |
| Glutarate SCHEMBL219714 | 0.88 | SLC22A6 (0.61) | LMNAAKR1B1GPR84PPARGPPARD | |
| Glutarate SCHEMBL5875071 | 0.88 | SLC22A6 (0.61) | LMNAAKR1B1GPR84PPARGPPARD | |
| Butyric Acid SCHEMBL834319 | 0.88 | FFAR3 (0.72) | LMNAEGLN1ALKBH5SUCNR1FFAR3 | |
| Adipic Acid SCHEMBL5875018 | 0.88 | AKR1B1 (0.62) | LMNAAKR1B1GPR84PPARGPPARD | |
| Adipic Acid SCHEMBL5875010 | 0.88 | AKR1B1 (0.62) | LMNAAKR1B1GPR84PPARGPPARD | |
| SCHEMBL6694020 | 0.86 | FFAR3 (0.46) | LMNAEGLN1ALKBH5SUCNR1FFAR3 | |
| SCHEMBL10891070 | 0.86 | GPR84 (0.64) | LMNAAKR1B1GPR84PPARGPPARD | |
| Sebacic Acid SCHEMBL5874637 | 0.86 | GPR84 (0.64) | LMNAAKR1B1GPR84PPARGPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 54 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114908343-B | Phosphorus-free prefilming agent for circulating cooling water and preparation method thereof | 山东天庆科技发展有限公司 | 2023-10-03 | — | — | CN | claimed |
| CN-114908343-A | Phosphorus-free prefilming agent for circulating cooling water and preparation method thereof | 山东天庆科技发展有限公司 | 2022-08-16 | — | — | CN | claimed |
| CN-106986911-B | The preparation method of dexamethasone key intermediate connection alkene sulfoxide object | 湖南玉新药业有限公司 | 2019-05-10 | — | — | CN | claimed |
| CN-106986908-B | The preparation method of betamethasone | 湖南玉新药业有限公司 | 2019-05-10 | — | — | CN | claimed |
| CN-106986908-A | The preparation method of betamethasone | 湖南玉新药业有限公司 | 2017-07-28 | — | — | CN | claimed |
| CN-106986911-A | Dexamethasone key intermediate joins the preparation method of alkene sulfoxide thing | 湖南玉新药业有限公司 | 2017-07-28 | — | — | CN | claimed |
| JP-5125308-A | — | — | None | — | — | JP | disclosed |
| US-20240101999-A1 | HIGH EFFICIENCY, SMALL VOLUME NUCLEIC ACID SYNTHESIS | THERMO FISHER SCIENTIFIC GENEART GMBH (DE) | 2024-03-28 | — | — | US | disclosed |
| CN-114908343-B | Phosphorus-free prefilming agent for circulating cooling water and preparation method thereof | 山东天庆科技发展有限公司 | 2023-10-03 | — | — | CN | disclosed |
| CN-114908343-B | Phosphorus-free prefilming agent for circulating cooling water and preparation method thereof | 山东天庆科技发展有限公司 | 2023-10-03 | — | — | CN | disclosed |
| CN-114409668-B | Isosorbide derivative and pit and groove sealing agent based on isosorbide structure | 上海交通大学医学院附属第九人民医院 | 2023-06-30 | — | — | CN | disclosed |
| CN-115927293-A | Efficient small volume nucleic acid synthesis | 生命技术公司 | 2023-04-07 | — | — | CN | disclosed |
| CN-107532129-B | Efficient small volume nucleic acid synthesis | 生命技术公司 | 2022-09-13 | — | — | CN | disclosed |
| WO-2003099238-A1 | ODOR CONTROL IN AMINE SALT CONTAINING COSMETIC COMPOSITIONS | UNILEVER PLC (GB) | 2003-12-04 | — | — | WO | disclosed |
| US-20030091838-A1 | Composition for film formation, method of film formation, and silica-based film | JSR CORPORATION (JP) | 2003-05-15 | — | — | US | disclosed |
| JP-H05125308-A | INK, INK-JET RECORDING METHOD USING THE SAME AND APPARATUS TO USE THE INK | CANON INC | 1993-05-21 | — | — | JP | disclosed |
| US-3963730-A | ACID CATALYST | SANKYO COMPANY LIMITED (JA) | 1976-06-15 | — | — | US | disclosed |
| US-3959295-A | ACETONE WITH AMMONIA, ACID CATALYSTS | CIBA-GEIGY CORPORATION (US) | 1976-05-25 | — | — | US | disclosed |
| US-3959298-A | ACETONINE WITH WATER IN ACID CATALYST | SANKYO COMPANY LIMITED (JA) | 1976-05-25 | — | — | US | disclosed |
| US-3953459-A | Process for the preparation of 2,2,6,6-tetramethyl-4-oxopiperidine | CIBA-GEIGY CORPORATION (US) | 1976-04-27 | — | — | US | disclosed |