Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.56 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.56 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.56 |
| ▸ | FFAR3 | O14843 | 2/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.53 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.50 |
| ▸ | PHF8 | Q9UPP1 | 3/20 | 0.46 |
| ▸ | KDM2A | Q9Y2K7 | 3/20 | 0.46 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.46 |
| ▸ | KDM6B | O15054 | 1/20 | 0.44 |
| ▸ | KDM5C | P41229 | 1/20 | 0.44 |
| ▸ | KDM7A | Q6ZMT4 | 1/20 | 0.44 |
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.43 |
| ▸ | PPARG | P37231 | 6/20 | 0.43 |
| ▸ | PPARD | Q03181 | 6/20 | 0.43 |
| ▸ | PPARA | Q07869 | 6/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinic Acid SCHEMBL217473 | 1.00 | LMNA (0.56) | LMNAEGLN1ALKBH5SUCNR1FFAR3 | |
| Succinic Acid SCHEMBL7441621 | 0.97 | LMNA (0.53) | LMNAEGLN1ALKBH5SUCNR1FFAR3 | |
| Glutarate SCHEMBL219714 | 0.88 | SLC22A6 (0.61) | LMNAAKR1B1GPR84PPARGPPARD | |
| Glutarate SCHEMBL5875071 | 0.88 | SLC22A6 (0.61) | LMNAAKR1B1GPR84PPARGPPARD | |
| Butyric Acid SCHEMBL834319 | 0.88 | FFAR3 (0.72) | LMNAEGLN1ALKBH5SUCNR1FFAR3 | |
| Adipic Acid SCHEMBL5875018 | 0.88 | AKR1B1 (0.62) | LMNAAKR1B1GPR84PPARGPPARD | |
| Adipic Acid SCHEMBL5875010 | 0.88 | AKR1B1 (0.62) | LMNAAKR1B1GPR84PPARGPPARD | |
| SCHEMBL6694020 | 0.86 | FFAR3 (0.46) | LMNAEGLN1ALKBH5SUCNR1FFAR3 | |
| SCHEMBL10891070 | 0.86 | GPR84 (0.64) | LMNAAKR1B1GPR84PPARGPPARD | |
| Sebacic Acid SCHEMBL5874637 | 0.86 | GPR84 (0.64) | LMNAAKR1B1GPR84PPARGPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240101999-A1 | HIGH EFFICIENCY, SMALL VOLUME NUCLEIC ACID SYNTHESIS | THERMO FISHER SCIENTIFIC GENEART GMBH (DE) | 2024-03-28 | — | — | US | disclosed |
| CN-115927293-A | Efficient small volume nucleic acid synthesis | 生命技术公司 | 2023-04-07 | — | — | CN | disclosed |
| CN-107532129-B | Efficient small volume nucleic acid synthesis | 生命技术公司 | 2022-09-13 | — | — | CN | disclosed |
| US-11041068-B2 | Solid support | LIFE TECHNOLOGIES AS (NO) | 2021-06-22 | — | — | US | disclosed |
| EP-3557262-A1 | HIGH EFFICIENCY, SMALL VOLUME NUCLEIC ACID SYNTHESIS | Life Technologies Corporation (US) | 2019-10-23 | — | — | EP | disclosed |
| US-10407676-B2 | High efficiency, small volume nucleic acid synthesis | Life Technologies Corporation (US) | 2019-09-10 | — | — | US | disclosed |
| US-20190264017-A1 | SOLID SUPPORT | LIFE TECHNOLOGIES AS (NO) | 2019-08-29 | — | — | US | disclosed |
| EP-3229959-B1 | HIGH EFFICIENCY, SMALL VOLUME NUCLEIC ACID SYNTHESIS | LIFE TECHNOLOGIES CORP (US) | 2019-05-15 | — | — | EP | disclosed |
| EP-3469009-A1 | SOLID SUPPORT | Life Technologies AS (NO) | 2019-04-17 | — | — | EP | disclosed |
| WO-2017211913-A1 | SOLID SUPPORT | LIFE TECHNOLOGIES AS (NO) | 2017-12-14 | — | — | WO | disclosed |
| CN-101835735-A | Bottom antireflective coating composition | AZ ELECTRONIC MATERIALS USA | 2010-09-15 | — | — | CN | disclosed |
| US-7128976-B2 | Composition for film formation, method of film formation, and silica-based film | JSR CORPORATION (JP) | 2006-10-31 | — | — | US | disclosed |
| EP-1509190-A1 | ODOR CONTROL IN AMINE SALT CONTAINING COSMETIC COMPOSITIONS | UNILEVER PLC (GB) | 2005-03-02 | — | — | EP | disclosed |
| US-20040185074-A1 | Odor control in amine salt containing cosmetic compositions | UNILEVER HOME & PERSONAL CARE USA, DIVISION OF CONOPCO, INC. | 2004-09-23 | — | — | US | disclosed |
| US-6677309-B1 | ANTHRACYCLINE DERIVATIVES | UNIVERSITY TECHNOLOGY CORPORATION | 2004-01-13 | — | — | US | disclosed |
| WO-2003099238-A1 | ODOR CONTROL IN AMINE SALT CONTAINING COSMETIC COMPOSITIONS | UNILEVER PLC (GB) | 2003-12-04 | — | — | WO | disclosed |
| US-20030091838-A1 | Composition for film formation, method of film formation, and silica-based film | JSR CORPORATION (JP) | 2003-05-15 | — | — | US | disclosed |
| EP-1015448-A4 | ANTI-CANCER DRUG ALDEHYDE CONJUGATE DRUGS WITH ENHANCED CYTOTOXICITY: COMPOUNDS, COMPOSITIONS AND METHODS | UNIV TECHNOLOGY CORP (US) | 2001-02-07 | — | — | EP | disclosed |
| EP-1015448-A1 | ANTI-CANCER DRUG ALDEHYDE CONJUGATE DRUGS WITH ENHANCED CYTOTOXICITY: COMPOUNDS, COMPOSITIONS AND METHODS | University Technology Corporation (US) | 2000-07-05 | — | — | EP | disclosed |
| WO-1998046598-A1 | ANTI-CANCER DRUG ALDEHYDE CONJUGATE DRUGS WITH ENHANCED CYTOTOXICITY: COMPOUNDS, COMPOSITIONS AND METHODS | UNIVERSITY TECHNOLOGY CORPORATION (US) | 1998-10-22 | — | — | WO | disclosed |