Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | NOS2 | P35228 | 6/20 | 0.52 |
| ▸ | NOS3 | P29474 | 4/20 | 0.52 |
| ▸ | NOS1 | P29475 | 4/20 | 0.52 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28330923 | 0.87 | NOS2 (0.50) | MAPTTDP1NOS2NOS3NOS1 | |
| SCHEMBL9378258 | 0.85 | NOS2 (0.44) | MAPTTDP1NOS2NOS3NOS1 | |
| SCHEMBL10344792 | 0.84 | NOS2 (0.48) | MAPTTDP1NOS2NOS3NOS1 | |
| SCHEMBL10830346 | 0.82 | NOS2 (0.42) | MAPTTDP1NOS2NOS3NOS1 | |
| SCHEMBL28267332 | 0.79 | MAPT (0.56) | MAPTTDP1NOS2NOS3NOS1 | |
| SCHEMBL29724038 | 0.75 | MAPT (0.52) | MAPTTDP1NOS2NOS3NOS1 | |
| SCHEMBL9521798 | 0.75 | NOS2 (0.52) | MAPTNOS2NOS3NOS1BACE1 | |
| SCHEMBL9738916 | 0.74 | NOS2 (0.53) | MAPTTDP1NOS2NOS3NOS1 | |
| SCHEMBL11811150 | 0.74 | HRH4 (0.38) | MAPTNOS2NOS3NOS1HRH4 | |
| SCHEMBL671139 | 0.74 | CASP1 (0.62) | NOS2NOS3NOS1HRH4ADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011079343-A2 | SUBSTITUTED PYRIDINES AND PYRIMIDINES | TECHNISCHE UNIVERSITAET WIEN (AT) | 2011-07-07 | — | — | WO | claimed |