Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | NOS3 | P29474 | 1/20 | 0.42 |
| ▸ | NOS1 | P29475 | 1/20 | 0.42 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.39 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10395258 | 0.87 | GPR84 (0.45) | NOS2NOS3NOS1TLR8ADORA3 | |
| SCHEMBL2175144 | 0.84 | MAPT (0.52) | NOS2MAPTTDP1NOS3NOS1 | |
| SCHEMBL9738916 | 0.82 | NOS2 (0.53) | NOS2MAPTTDP1NOS3NOS1 | |
| SCHEMBL19614413 | 0.81 | HCAR2 (0.48) | NOS2MAPTTDP1TLR8ADORA3 | |
| SCHEMBL92739 | 0.78 | KCNH2 (0.46) | TDP1ADORA3ADORA2AADORA2BADORA1 | |
| SCHEMBL1639952 | 0.77 | CASP1 (0.68) | TLR8ADORA3ADORA2AADORA2BADORA1 | |
| SCHEMBL10400012 | 0.77 | PTGS2 (0.53) | NOS2MAPTTLR8GPR84CYP3A4 | |
| SCHEMBL6530888 | 0.76 | TLR8 (0.41) | NOS2MAPTTDP1TLR8ADORA3 | |
| SCHEMBL31054446 | 0.76 | KCNH2 (0.50) | ADORA3ADORA2AKCNH2GPR84CYP3A4 | |
| SCHEMBL7711334 | 0.76 | KCNH2 (0.50) | ADORA3ADORA2AKCNH2GPR84CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0274356-B1 | VATTABLE 2-ARYL-4,6-DIAMINOPYRIMIDINE | CIBA-GEIGY AG (CH) | 1990-05-16 | — | — | EP | claimed |
| US-4845220-A | Vattable 2-aryl-4,6-diaminopyrimidines | CIBA-GEIGY CORPORATION | 1989-07-04 | — | — | US | claimed |
| EP-0274356-A1 | Vattable 2-aryl-4,6-diaminopyrimidine | CIBA-GEIGY AG (CH) | 1988-07-13 | — | — | EP | claimed |
| EP-0274356-B1 | VATTABLE 2-ARYL-4,6-DIAMINOPYRIMIDINE | CIBA-GEIGY AG (CH) | 1990-05-16 | — | — | EP | disclosed |
| EP-0274356-B1 | VATTABLE 2-ARYL-4,6-DIAMINOPYRIMIDINE | CIBA-GEIGY AG (CH) | 1990-05-16 | — | — | EP | disclosed |
| US-4845220-A | Vattable 2-aryl-4,6-diaminopyrimidines | CIBA-GEIGY CORPORATION | 1989-07-04 | — | — | US | disclosed |
| US-4845220-A | Vattable 2-aryl-4,6-diaminopyrimidines | CIBA-GEIGY CORPORATION | 1989-07-04 | — | — | US | disclosed |
| US-4845220-A | Vattable 2-aryl-4,6-diaminopyrimidines | CIBA-GEIGY CORPORATION | 1989-07-04 | — | — | US | disclosed |
| EP-0274356-A1 | Vattable 2-aryl-4,6-diaminopyrimidine | CIBA-GEIGY AG (CH) | 1988-07-13 | — | — | EP | disclosed |
| EP-0274356-A1 | Vattable 2-aryl-4,6-diaminopyrimidine | CIBA-GEIGY AG (CH) | 1988-07-13 | — | — | EP | disclosed |
| US-3950525-A | BRONCHODILATION, 4-HYDROXY-6-ARYL PYRIMIDINES | PFIZER INC. (US) | 1976-04-13 | — | — | US | disclosed |