Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 7/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | THRB | P10828 | 2/20 | 0.38 |
| ▸ | RECQL | P46063 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | APEX1 | P27695 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 2/20 | 0.36 |
| ▸ | CA1 | P00915 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10778251 | 0.77 | CYP3A4 (0.41) | TSHRCYP3A4TP53TDP1MAPK1 | |
| SCHEMBL10494560 | 0.75 | CYP3A4 (0.43) | TSHRCYP3A4TP53ALDH1A1TDP1 | |
| SCHEMBL174757 | 0.75 | CYP3A4 (0.46) | TSHRCYP3A4TP53ALDH1A1TDP1 | |
| SCHEMBL526351 | 0.73 | ALDH1A1 (0.50) | TSHRCYP3A4TP53ALDH1A1TDP1 | |
| SCHEMBL2159908 | 0.73 | IDO1 (0.39) | TSHRCYP3A4TP53ALDH1A1TDP1 | |
| SCHEMBL28685336 | 0.73 | IDO1 (0.39) | TSHRCYP3A4TP53ALDH1A1TDP1 | |
| Hydrochloric Acid SCHEMBL8714149 | 0.72 | CYP3A4 (0.46) | TSHRCYP3A4TP53ALDH1A1TDP1 | |
| SCHEMBL1813012 | 0.72 | TSHR (0.42) | TSHRCYP3A4TP53ALDH1A1TDP1 | |
| SCHEMBL24048409 | 0.72 | PNMT (0.40) | TSHRCYP3A4ALDH1A1TDP1THRB | |
| Ethylene SCHEMBL15522510 | 0.70 | CYP3A4 (0.42) | TSHRCYP3A4TP53ALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3840755-A1 | THYROID HORMONE RECEPTOR BETA AGONIST COMPOUNDS | Terns, Inc. (US) | 2021-06-30 | — | — | EP | disclosed |
| WO-2020041741-A1 | THYROID HORMONE RECEPTOR BETA AGONIST COMPOUNDS | Terns, Inc. (US) | 2020-02-27 | — | — | WO | disclosed |