Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 2/20 | 0.40 |
| ▸ | AOC1 | P19801 | 2/20 | 0.33 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | APEX1 | P27695 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21752116 | 0.72 | TSHR (0.39) | ALDH1A1TDP1MEN1NPC1POLB | |
| SCHEMBL5591177 | 0.70 | PNMT (0.62) | PNMTAOC1AOC3ALDH1A1TDP1 | |
| SCHEMBL10494560 | 0.68 | CYP3A4 (0.43) | ALDH1A1TDP1MEN1NPC1POLB | |
| SCHEMBL11399402 | 0.68 | CTRC (0.35) | ALDH1A1TDP1MEN1NPC1POLB | |
| SCHEMBL48329 | 0.67 | CYP3A4 (0.39) | PNMTALDH1A1TDP1MEN1NPC1 | |
| SCHEMBL29987755 | 0.67 | CYP3A4 (0.39) | PNMTALDH1A1TDP1MEN1NPC1 | |
| SCHEMBL526351 | 0.66 | ALDH1A1 (0.50) | ALDH1A1TDP1MEN1NPC1POLB | |
| SCHEMBL8848222 | 0.64 | AOC1 (0.39) | PNMTAOC1AOC3DPP4 | |
| SCHEMBL671453 | 0.64 | PNMT (0.54) | PNMTAOC1AOC3ALDH1A1DPP4 | |
| SCHEMBL21852155 | 0.64 | POLB (0.40) | ALDH1A1TDP1MEN1NPC1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021236775-A1 | SMALL MOLECULE DEGRADERS OF SHP2 PROTEIN | THE REGENTS OF THE UNIVERSITY OFMICHIGAN (US) | 2021-11-25 | — | — | WO | disclosed |