Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGFR | P43088 | 10/20 | 0.78 |
| ▸ | PTGER3 | P43115 | 4/20 | 0.78 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.66 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.66 |
| ▸ | TBXA2R | P21731 | 4/20 | 0.63 |
| ▸ | PTGER1 | P34995 | 3/20 | 0.63 |
| ▸ | SLCO2A1 | Q92959 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.58 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.58 |
| ▸ | THRB | P10828 | 1/20 | 0.55 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25177987 | 0.91 | PTGFR (0.75) | PTGFRPTGER3ABCB11AKR1C3TBXA2R | |
| SCHEMBL25177988 | 0.91 | PTGFR (0.75) | PTGFRPTGER3ABCB11AKR1C3TBXA2R | |
| SCHEMBL13137214 | 0.91 | ABCB11 (0.81) | PTGFRPTGER3ABCB11AKR1C3TBXA2R | |
| SCHEMBL8647254 | 0.90 | PTGFR (0.63) | PTGFRPTGER3ABCB11AKR1C3TBXA2R | |
| SCHEMBL12087462 | 0.88 | PTGFR (0.82) | PTGFRPTGER3ABCB11AKR1C3TBXA2R | |
| SCHEMBL12138632 | 0.88 | PTGFR (1.00) | PTGFRPTGER3ABCB11AKR1C3TBXA2R | |
| SCHEMBL17377176 | 0.88 | PTGFR (1.00) | PTGFRPTGER3ABCB11AKR1C3TBXA2R | |
| SCHEMBL14957832 | 0.88 | PTGFR (1.00) | PTGFRPTGER3ABCB11AKR1C3TBXA2R | |
| SCHEMBL14599104 | 0.88 | PTGFR (1.00) | PTGFRPTGER3ABCB11AKR1C3TBXA2R | |
| SCHEMBL15676006 | 0.88 | PTGFR (1.00) | PTGFRPTGER3ABCB11AKR1C3TBXA2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10568878-B2 | Combination therapy | AERIE PHARMACEUTICALS, INC. (US) | 2020-02-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10568878-B2 | Combination therapy | PTGS1, PTGS2, PTGIS | PTGFR 12/4885PTGER3 11/4885ABCB11 802/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.