Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.41 |
| ▸ | ANO2 | Q9NQ90 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 3/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | EIF2AK1 | Q9BQI3 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2171484 | 0.79 | POLB (0.49) | MAPTMEN1KMT2ATP53POLB | |
| SCHEMBL2175482 | 0.76 | ROCK2 (0.49) | MAPTNPC1ALDH1A1GAAMEN1 | |
| SCHEMBL2171311 | 0.75 | ALDH1A1 (0.45) | MAPTNPC1KDM4EALDH1A1KMT2A | |
| SCHEMBL2172661 | 0.73 | CDK2 (0.54) | MAPTNPC1ALDH1A1GAAL3MBTL1 | |
| SCHEMBL2173548 | 0.72 | FLT3 (0.56) | MAPTNPC1KDM4EALDH1A1GAA | |
| SCHEMBL2173092 | 0.72 | PIK3CA (0.44) | MAPTKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL2175776 | 0.71 | NPC1 (0.48) | MAPTNPC1KDM4EALDH1A1GAA | |
| SCHEMBL2175786 | 0.71 | KDM4E (0.38) | MAPTKDM4EALDH1A1GAAROCK2 | |
| SCHEMBL2173919 | 0.70 | GPBAR1 (0.44) | MAPTKDM4EALDH1A1GAATP53 | |
| SCHEMBL2173329 | 0.70 | GPBAR1 (0.47) | MAPTKDM4EALDH1A1KMT2ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2346832-A1 | TRICYCLIC COMPOUNDS AS GLUTAMATE RECEPTOR MODULATORS | Glaxo Group Limited (GB) | 2011-07-27 | — | — | EP | disclosed |
| WO-2010049366-A1 | TRICYCLIC COMPOUNDS AS GLUTAMATE RECEPTOR MODULATORS | GLAXO GROUP LIMITED (GB) | 2010-05-06 | — | — | WO | disclosed |