Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 15/20 | 0.40 |
| ▸ | MPL | P40238 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | ALPL | P05186 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.35 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.35 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.35 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.35 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.35 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.35 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2171831 | 0.85 | HCAR2 (0.40) | HCAR2KDM4EALDH1A1ALPLHSD17B10 | |
| SCHEMBL2172150 | 0.85 | KDM4E (0.37) | MPLKDM4EALDH1A1ALPLHSD17B10 | |
| SCHEMBL4727175 | 0.76 | HCAR2 (0.39) | HCAR2KDM4EALDH1A1ALPLHSD17B10 | |
| SCHEMBL3520429 | 0.75 | HCAR2 (0.41) | HCAR2KDM4EALDH1A1ALPLHSD17B10 | |
| SCHEMBL3518121 | 0.75 | ALDH1A1 (0.43) | KDM4EALDH1A1ALPLHSD17B10PRKAB2 | |
| SCHEMBL3747711 | 0.75 | KMT2A (0.44) | HCAR2KDM4EALDH1A1ALPLHSD17B10 | |
| SCHEMBL2171482 | 0.74 | KDM4E (0.59) | HCAR2KDM4EALDH1A1ALPLHSD17B10 | |
| SCHEMBL4728060 | 0.72 | ALPL (0.43) | HCAR2KDM4EALDH1A1ALPLHSD17B10 | |
| SCHEMBL4728706 | 0.72 | ALPL (0.43) | HCAR2KDM4EALDH1A1ALPLHSD17B10 | |
| SCHEMBL2171236 | 0.71 | L3MBTL1 (0.38) | KDM4EALDH1A1ALPLHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2346832-A1 | TRICYCLIC COMPOUNDS AS GLUTAMATE RECEPTOR MODULATORS | Glaxo Group Limited (GB) | 2011-07-27 | — | — | EP | disclosed |
| WO-2010049366-A1 | TRICYCLIC COMPOUNDS AS GLUTAMATE RECEPTOR MODULATORS | GLAXO GROUP LIMITED (GB) | 2010-05-06 | — | — | WO | disclosed |