Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.38 |
| ▸ | GLA | P06280 | 6/20 | 0.38 |
| ▸ | PIM1 | P11309 | 3/20 | 0.38 |
| ▸ | RUNX1 | Q01196 | 1/20 | 0.38 |
| ▸ | CBFB | Q13951 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 4/20 | 0.37 |
| ▸ | ATM | Q13315 | 3/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.36 |
| ▸ | ALPL | P05186 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2172365 | 0.78 | HCRTR2 (0.40) | KDM4EGLAPIM1RUNX1CBFB | |
| SCHEMBL2171311 | 0.75 | ALDH1A1 (0.45) | KDM4EGLAHSD17B10ALDH1A1ROCK2 | |
| SCHEMBL2548371 | 0.73 | ALDH1A1 (0.48) | KDM4EPIM1HSD17B10ALDH1A1MAPK1 | |
| SCHEMBL2175753 | 0.71 | MAPT (0.47) | KDM4EHSD17B10ALDH1A1GAAROCK2 | |
| SCHEMBL2171482 | 0.70 | KDM4E (0.59) | KDM4EGLAPIM1RUNX1CBFB | |
| SCHEMBL2175482 | 0.70 | ROCK2 (0.49) | ALDH1A1MAPK1GAAROCK2POLB | |
| SCHEMBL30290797 | 0.69 | KDM4E (0.51) | KDM4EGLAPIM1RUNX1CBFB | |
| SCHEMBL2173401 | 0.68 | MEN1 (0.54) | KDM4EHSD17B10ALDH1A1ROCK2MAPT | |
| SCHEMBL16517596 | 0.66 | VNN1 (0.41) | KDM4EALDH1A1MAPK1ADORA2AADORA1 | |
| SCHEMBL2175776 | 0.66 | NPC1 (0.48) | KDM4EHSD17B10MAPK10ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2346832-A1 | TRICYCLIC COMPOUNDS AS GLUTAMATE RECEPTOR MODULATORS | Glaxo Group Limited (GB) | 2011-07-27 | — | — | EP | disclosed |
| WO-2010049366-A1 | TRICYCLIC COMPOUNDS AS GLUTAMATE RECEPTOR MODULATORS | GLAXO GROUP LIMITED (GB) | 2010-05-06 | — | — | WO | disclosed |