Sugi Predict

Sugi Predict / Compounds / SCHEMBL2175952

SCHEMBL2175952

SCHEMBL2175952

COC(=O)c1ccc(CO)n1C

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ NPC1 O15118 2/20 0.44
▸ KDM4E B2RXH2 2/20 0.44
▸ NPSR1 Q6W5P4 3/20 0.43
▸ MAPK1 P28482 1/20 0.42
▸ ATM Q13315 1/20 0.42
▸ L3MBTL1 Q9Y468 2/20 0.41
▸ ALDH1A1 P00352 2/20 0.39
▸ SMN1; SMN2 Q16637 1/20 0.38
▸ RAB9A P51151 2/20 0.38
▸ MEN1 O00255 1/20 0.38
▸ KMT2A Q03164 1/20 0.38
▸ CXCL8 P10145 1/20 0.37
▸ AKR1B1 P15121 1/20 0.37
▸ PTGS1 P23219 1/20 0.37
▸ PTGS2 P35354 1/20 0.37
▸ GLO1 Q04760 1/20 0.37
▸ HPGD P15428 2/20 0.36
▸ MAPT P10636 2/20 0.35
▸ TSHR P16473 1/20 0.35
▸ CYP4A11 Q02928 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2176691 0.84 LOXL2 (0.44) NPC1KDM4ENPSR1MAPK1ATM
SCHEMBL69407 0.82 KDM4E (0.53) NPC1KDM4ENPSR1MAPK1ATM
SCHEMBL19434591 0.80 NPC1 (0.39) NPC1KDM4ENPSR1MAPK1ATM
SCHEMBL15564208 0.75 NPSR1 (0.51) NPC1KDM4ENPSR1MAPK1ATM
SCHEMBL13804468 0.75 NPC1 (0.47) NPC1KDM4ENPSR1MAPK1ATM
SCHEMBL7860405 0.75 NPC1 (0.47) NPC1KDM4ENPSR1MAPK1ATM
SCHEMBL12748885 0.75 NPC1 (0.47) NPC1KDM4ENPSR1MAPK1ATM
SCHEMBL29244595 0.74 NPC1 (0.48) NPC1KDM4ENPSR1MAPK1ATM
SCHEMBL1125985 0.74 CYP4F2 (0.44) KDM4EL3MBTL1ALDH1A1SMN1; SMN2MEN1
SCHEMBL2173361 0.74 POLB (0.46) NPSR1MAPK1ALDH1A1SMN1; SMN2MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3440073-B1 KINASE INHIBITORS OXULAR ACQUISITIONS LTD (GB) 2022-06-08 — — EP disclosed
US-10442828-B2 Kinase inhibitors TOPIVERT PHARMA LIMITED (GB) 2019-10-15 — — US disclosed
EP-3440073-A1 KINASE INHIBITORS Topivert Pharma Limited (GB) 2019-02-13 — — EP disclosed
US-20190000832-A1 TETRAHYDROISOQUINOLIN-1-ONE DERIVATIVE OR SALT THEREOF Selder Pharma Inc. (US) 2019-01-03 — — US disclosed
US-20180305383-A1 KINASE INHIBITORS OXULAR ACQUISITIONS LIMITED (GB) 2018-10-25 — — US disclosed
US-10072034-B2 Kinase inhibitors RESPIVERT LIMITED (GB) 2018-09-11 — — US disclosed
US-10016410-B2 Tetrahydroisoquinolin-1-one derivative or salt thereof SELDAR PHARMA INC. (US) 2018-07-10 — — US disclosed
US-10016410-B2 Tetrahydroisoquinolin-1-one derivative or salt thereof SELDAR PHARMA INC. (US) 2018-07-10 — — US disclosed
US-20170291917-A1 KINASE INHIBITORS OXULAR ACQUISITIONS LIMITED (GB) 2017-10-12 — — US disclosed
WO-2017174995-A1 KINASE INHIBITORS RESPIVERT LIMITED (GB) 2017-10-12 — — WO disclosed
US-8486970-B2 Tetrahydroisoquinolin-1-one derivative or salt thereof SELDAR PHARMA INC. (US) 2013-07-16 — — US disclosed
US-7973078-B2 Sulfonamide compound or salt thereof ASTELLAS PHARMA INC. (JP) 2011-07-05 — — US disclosed
US-7973078-B2 Sulfonamide compound or salt thereof ASTELLAS PHARMA INC. (JP) 2011-07-05 — — US disclosed
US-7973078-B2 Sulfonamide compound or salt thereof ASTELLAS PHARMA INC. (JP) 2011-07-05 — — US disclosed
US-20100227866-A1 TETRAHYDROISOQUINOLIN-1-ONE DERIVATIVE OR SALT THEREOF ASTELLAS PHARMA INC. (JP) 2010-09-09 — — US disclosed
US-20100227866-A1 TETRAHYDROISOQUINOLIN-1-ONE DERIVATIVE OR SALT THEREOF ASTELLAS PHARMA INC. (JP) 2010-09-09 — — US disclosed
US-20090312328-A1 SULFONAMIDE COMPOUND OR SALT THEREOF ASTELLAS PHARMA INC. (JP) 2009-12-17 — — US disclosed
US-20090312328-A1 SULFONAMIDE COMPOUND OR SALT THEREOF ASTELLAS PHARMA INC. (JP) 2009-12-17 — — US disclosed
US-20090312328-A1 SULFONAMIDE COMPOUND OR SALT THEREOF ASTELLAS PHARMA INC. (JP) 2009-12-17 — — US disclosed
EP-2050446-A1 SULFONAMIDE COMPOUND OR SALT THEREOF Astellas Pharma Inc. (JP) 2009-04-22 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10072034-B2 Kinase inhibitors SYK, LYN, BTK NPC1 4825/4885KDM4E 2053/4885NPSR1 1649/4885
US-10016410-B2 Tetrahydroisoquinolin-1-one derivative or salt thereof BRS3, BDKRB2, NTSR2 NPC1 2242/4885KDM4E 4440/4885NPSR1 37/4885
US-20180305383-A1 KINASE INHIBITORS SYK, LTK, LTB4R NPC1 4645/4885KDM4E 2216/4885NPSR1 1074/4885
US-20090312328-A1 SULFONAMIDE COMPOUND OR SALT THEREOF PTGER1, CYSLTR1, PTGER2 NPC1 2796/4885KDM4E 4231/4885NPSR1 32/4885
US-10442828-B2 Kinase inhibitors SYK, LTK, LTB4R NPC1 4645/4885KDM4E 2216/4885NPSR1 1074/4885
US-20100227866-A1 TETRAHYDROISOQUINOLIN-1-ONE DERIVATIVE OR SALT THEREOF BRS3, BDKRB2, NTSR2 NPC1 2206/4885KDM4E 4486/4885NPSR1 35/4885
US-20170291917-A1 KINASE INHIBITORS SYK, LYN, BTK NPC1 4825/4885KDM4E 2053/4885NPSR1 1649/4885
US-20190000832-A1 TETRAHYDROISOQUINOLIN-1-ONE DERIVATIVE OR SALT THEREOF BRS3, BDKRB2, NTSR2 NPC1 2242/4885KDM4E 4440/4885NPSR1 37/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.