Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 10/20 | 0.71 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | RECQL | P46063 | 1/20 | 0.56 |
| ▸ | HTR7 | P34969 | 4/20 | 0.54 |
| ▸ | HTR6 | P50406 | 3/20 | 0.51 |
| ▸ | HTR3E | A5X5Y0 | 5/20 | 0.50 |
| ▸ | HTR3B | O95264 | 5/20 | 0.50 |
| ▸ | HTR3A | P46098 | 5/20 | 0.50 |
| ▸ | HTR3D | Q70Z44 | 5/20 | 0.50 |
| ▸ | HTR3C | Q8WXA8 | 5/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.50 |
| ▸ | HTR5A | P47898 | 1/20 | 0.50 |
| ▸ | HTR1A | P08908 | 4/20 | 0.49 |
| ▸ | HTR1D | P28221 | 1/20 | 0.46 |
| ▸ | HTR1B | P28222 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14419500 | 0.86 | ADRB1 (0.71) | ADRB1MAPTRECQLHTR7HTR6 | |
| SCHEMBL6151312 | 0.84 | ADRB1 (0.69) | ADRB1MAPTRECQLHTR7HTR6 | |
| SCHEMBL6151880 | 0.84 | ADRB1 (0.69) | ADRB1MAPTRECQLHTR7HTR6 | |
| SCHEMBL221254 | 0.83 | ADRB1 (1.00) | ADRB1HTR7HTR6HTR3EHTR3B | |
| SCHEMBL3343700 | 0.83 | S100B (0.61) | ADRB1MAPTRECQLTP53THRB | |
| SCHEMBL8071214 | 0.83 | MAPT (0.61) | ADRB1MAPTRECQLHTR7HTR6 | |
| SCHEMBL20043806 | 0.81 | S100B (0.65) | ADRB1MAPTRECQLTP53THRB | |
| SCHEMBL5206787 | 0.80 | ADRB1 (0.63) | ADRB1MAPTRECQLHTR7HTR6 | |
| SCHEMBL1527203 | 0.80 | GAA (0.64) | ADRB1MAPTRECQLHTR6HTR3A | |
| SCHEMBL2984679 | 0.80 | ADRB1 (0.73) | ADRB1MAPTHTR7HTR6HTR3E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020038415-A1 | TROPOMYOSIN RECEPTOR KINASE (TRK) DEGRADATION COMPOUNDS AND METHODS OF USE | CULLGEN (SHANGHAI), INC. (CN) | 2020-02-27 | — | — | WO | disclosed |