SCHEMBL221254

SCHEMBL221254

Cc1ccc(N2CCNCC2)cc1C

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADRB1 P08588 11/20 1.00
HTR7 P34969 5/20 0.68
HTR3A P46098 6/20 0.55
HTR3E A5X5Y0 5/20 0.55
HTR3B O95264 5/20 0.55
HTR3D Q70Z44 5/20 0.55
HTR3C Q8WXA8 5/20 0.55
SIGMAR1 Q99720 5/20 0.55
HTR5A P47898 1/20 0.55
HTR1A P08908 5/20 0.53
CYP1A2 P05177 2/20 0.50
CYP3A4 P08684 2/20 0.50
CYP2D6 P10635 2/20 0.50
CYP2C9 P11712 2/20 0.50
HTR1D P28221 1/20 0.50
HTR1B P28222 1/20 0.50
TP53 P04637 1/20 0.50
THRB P10828 1/20 0.50
HTR2A P28223 1/20 0.50
HTR2C P28335 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5231120 0.93 ADRB1 (0.86) ADRB1HTR7HTR3AHTR3EHTR3B
SCHEMBL1422991 0.90 ADRB1 (0.81) ADRB1HTR7HTR3AHTR3EHTR3B
SCHEMBL27642375 0.90 ADRB1 (0.81) ADRB1HTR7HTR3AHTR3EHTR3B
SCHEMBL2984679 0.85 ADRB1 (0.73) ADRB1HTR7HTR3AHTR3EHTR3B
SCHEMBL13900671 0.85 ADRB1 (0.73) ADRB1HTR7HTR3AHTR3EHTR3B
SCHEMBL20171856 0.83 ADRB1 (0.71) ADRB1HTR7HTR3AHTR3EHTR3B
SCHEMBL15217395 0.83 ADRB1 (0.71) ADRB1HTR7HTR3AHTR3EHTR3B
SCHEMBL2874530 0.83 ADRB1 (0.71) ADRB1HTR7HTR3AHTR3EHTR3B
SCHEMBL21760107 0.83 ADRB1 (0.71) ADRB1HTR7HTR3AHTR3EHTR3B
SCHEMBL6964650 0.83 ADRB1 (0.71) ADRB1HTR7HTR3AHTR3EHTR3B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 555 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20140273458-A1 Chemical Mechanical Planarization for Tungsten-Containing Substrates AIR PRODUCTS AND CHEMICALS, INC. (US) 2014-09-18 US claimed
EP-2779217-A2 Chemical mechanical planarization for tungsten-containing substrates AIR PRODUCTS AND CHEMICALS, INC. (US) 2014-09-17 EP claimed
CN-104046246-A Chemical Mechanical Planarization for Tungsten-Containing Substrates AIR PROD & CHEM 2014-09-17 CN claimed
US-20260092134-A1 Bioreducible Poly (Beta-Amino Ester)s For siRNA Delivery UNIV JOHNS HOPKINS (US) 2026-04-02 US disclosed
US-12527746-B2 Peptide/particle delivery systems THE JOHNS HOPKINS UNIVERSITY (US) 2026-01-20 US disclosed
EP-4642434-A2 LIPID COMPOSITIONS ON THE BASIS OF IONIZABLE LIPIDS, USE FOR DELIVERY TO IMMUNE CELLS Life Technologies Corporation (US) 2025-11-05 EP disclosed
US-12458700-B2 Amine-containing transfection reagents and methods for making and using same Life Technologies Corporation (US) 2025-11-04 US disclosed
US-12371522-B2 Bioreducible poly (beta-amino ester)s for siRNA delivery THE JOHNS HOPKINS UNIVERSITY (US) 2025-07-29 US disclosed
US-20250136737-A1 MULTICOMPONENT DEGRADABLE CATIONIC POLYMERS THE JOHNS HOPKINS UNIVERSITY 2025-05-01 US disclosed
US-20240263196-A1 Lipid Compositions and Methods for Delivery to Immune Cells Life Technologies Corporation 2024-08-08 US disclosed
US-12049530-B2 Multicomponent degradable cationic polymers THE JOHNS HOPKINS UNIVERISTY (US) 2024-07-30 US disclosed
US-4940705-A VIRICIDES BAYER AKTIENGESELLSCHAFT (DE) 1990-07-10 US disclosed
EP-0322643-A1 Medicines containing as a mixture interferon and 1-desoxy-piperidinoses, process for their manufacture and their use BAYER AG (DE) 1989-07-05 EP disclosed
EP-0313974-A1 N-substituted derivatives of 1-desoxynojirimycine and 1-desoxymannonojirimycine, process for their preparation and their use as pharmaceuticals BAYER AG (DE) 1989-05-03 EP disclosed
EP-0114374-B1 SUBSTITUTED 4-AMINOMETHYLENE CHROMANS OR CHROMENES, PROCESS FOR THEIR PREPARATION AND THEIR USE IN MEDICINES BAYER AG (DE) 1986-07-23 EP disclosed
US-4563458-A CIRCULATORY SYSTEM DISORDERS BAYER AKTIENGESELLSCHAFT (DE) 1986-01-07 US disclosed
EP-0114374-A1 Substituted 4-aminomethylene chromans or chromenes, process for their preparation and their use in medicines BAYER AG (DE) 1984-08-01 EP disclosed
US-4370329-A Piperazine derivatives as circulation-enhancing substances MERZ & COMPANY (DE) 1983-01-25 US disclosed
US-4370330-A Method of enhancing circulation with piperazines MERZ & COMPANY (DE) 1983-01-25 US disclosed
US-3983121-A 1-Substituted 4-(β-2-quinolylethyl)piperazines and 1,2,3,4-tetrahydroquinolyl-ethyl analogues thereof COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) 1976-09-28 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12527746-B2 Peptide/particle delivery systems VEGFA, IGF2BP2, MSTN ADRB1 1326/4885HTR7 1145/4885HTR3A 2147/4885
US-20250136737-A1 MULTICOMPONENT DEGRADABLE CATIONIC POLYMERS PEF1, FIBP, PARN ADRB1 4466/4885HTR7 1197/4885HTR3A 1018/4885
US-12458700-B2 Amine-containing transfection reagents and methods for making and using same SNRPA, NUDT21, SOAT2 ADRB1 2390/4885HTR7 826/4885HTR3A 2204/4885
US-12371522-B2 Bioreducible poly (beta-amino ester)s for siRNA delivery AARS1, SLC43A1, PHAX ADRB1 1085/4885HTR7 3448/4885HTR3A 4002/4885
US-12049530-B2 Multicomponent degradable cationic polymers PEF1, FIBP, PARN ADRB1 4466/4885HTR7 1197/4885HTR3A 1018/4885
US-20260092134-A1 Bioreducible Poly (Beta-Amino Ester)s For siRNA Delivery SLC43A1, SLC7A5, SLC7A1 ADRB1 961/4885HTR7 4194/4885HTR3A 4257/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.