Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 1/20 | 0.54 |
| ▸ | CYP2A6 | P11509 | 4/20 | 0.53 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.47 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.47 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.42 |
| ▸ | GAB1 | Q13480 | 1/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30729957 | 0.86 | PDPK1 (0.44) | CA2CYP2A6KEAP1NFE2L2TRPV4 | |
| SCHEMBL7213509 | 0.86 | PDPK1 (0.44) | CA2CYP2A6KEAP1NFE2L2TRPV4 | |
| SCHEMBL2177013 | 0.81 | CA2 (0.52) | CA2CYP2A6MAPTLMNATP53 | |
| SCHEMBL6633924 | 0.80 | CYP2A6 (0.51) | CA2CYP2A6KEAP1NFE2L2GAB1 | |
| SCHEMBL4210638 | 0.77 | CYP2A6 (0.83) | CA2CYP2A6KEAP1NFE2L2GAB1 | |
| SCHEMBL2089910 | 0.77 | MTNR1A (0.45) | CA2TRPV4KDM4EMAPT | |
| SCHEMBL288542 | 0.76 | CA1 (0.47) | CA2CYP2A6PDPK1KDM4EMAPT | |
| SCHEMBL29469856 | 0.76 | CA1 (0.47) | CA2CYP2A6PDPK1KDM4EMAPT | |
| SCHEMBL29017448 | 0.72 | CYP2A6 (0.64) | CA2CYP2A6KEAP1NFE2L2KDM4E | |
| SCHEMBL2176655 | 0.72 | NPC1 (0.42) | CA2KDM4EMAPTSMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7973051-B2 | Aminothiazoles as FBPase inhibitors for diabetes | HOFFMAN-LA ROCHE INC. (US) | 2011-07-05 | — | — | US | disclosed |
| EP-2227468-A1 | AMINOTHIAZOLE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2010-09-15 | — | — | EP | disclosed |
| US-20090143448-A1 | NEW AMINOTHIAZOLES AS FBPASE INHIBITORS FOR DIABETES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-06-04 | — | — | US | disclosed |
| WO-2009068467-A1 | AMINOTHIAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-06-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090143448-A1 | NEW AMINOTHIAZOLES AS FBPASE INHIBITORS FOR DIABETES | FBP1, SLC5A1, DPP4 | CA2 1616/4885CYP2A6 1152/4885KEAP1 538/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.