Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | GLA | P06280 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | WDR5 | P61964 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | ACLY | P53396 | 1/20 | 0.46 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.46 |
| ▸ | ALPL | P05186 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21760973 | 0.86 | SMN1; SMN2 (0.51) | SMN1; SMN2TSHRGLAGAAALDH1A1 | |
| SCHEMBL21760970 | 0.86 | SMN1; SMN2 (0.51) | KMT2ASMN1; SMN2TSHRGLAGAA | |
| SCHEMBL21760972 | 0.84 | ALPL (0.60) | KMT2ASMN1; SMN2TSHRGLAGAA | |
| SCHEMBL21760971 | 0.82 | SMN1; SMN2 (0.48) | KMT2ASMN1; SMN2TSHRGLAGAA | |
| SCHEMBL21761089 | 0.81 | SMN1; SMN2 (0.67) | KMT2ASMN1; SMN2TSHRGLAGAA | |
| SCHEMBL31113449 | 0.79 | ALDH1A1 (0.74) | SMN1; SMN2GLAALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL21761090 | 0.77 | SMN1; SMN2 (0.54) | KMT2ASMN1; SMN2TSHRGLAGAA | |
| SCHEMBL31568119 | 0.77 | PKM (0.65) | KMT2ATSHRGAAALDH1A1CYP1A2 | |
| SCHEMBL21177215 | 0.76 | SMN1; SMN2 (0.56) | SMN1; SMN2TSHRGLAGAAALDH1A1 | |
| SCHEMBL21760687 | 0.75 | SMN1; SMN2 (0.55) | SMN1; SMN2TSHRGLAGAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3842439-A1 | BICYCLIC HETEROAROMATIC RING DERIVATIVE | Kyorin Pharmaceutical Co., Ltd. (JP) | 2021-06-30 | — | — | EP | disclosed |
| WO-2020040104-A1 | BICYCLIC HETEROAROMATIC RING DERIVATIVE | 杏林製薬株式会社 | 2020-02-27 | — | — | WO | disclosed |