Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | BCHE | P06276 | 1/20 | 0.46 |
| ▸ | CASR | P41180 | 1/20 | 0.45 |
| ▸ | IDO1 | P14902 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.43 |
| ▸ | SLC18A2 | Q05940 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL143708 | 0.81 | SIGMAR1 (0.65) | SIGMAR1POLBKDM4ECYP3A4MAPT | |
| SCHEMBL22899588 | 0.81 | SIGMAR1 (0.65) | SIGMAR1POLBKDM4ECYP3A4MAPT | |
| SCHEMBL3413593 | 0.81 | SIGMAR1 (0.65) | SIGMAR1POLBKDM4ECYP3A4MAPT | |
| SCHEMBL22136863 | 0.80 | SMN1; SMN2 (0.55) | SIGMAR1POLBKDM4EMAPTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL1331235 | 0.79 | SIGMAR1 (0.63) | SIGMAR1POLBKDM4ECYP3A4MAPT | |
| Bromide SCHEMBL1331742 | 0.79 | SIGMAR1 (0.63) | SIGMAR1POLBKDM4ECYP3A4MAPT | |
| Ammonia Solution, Strong SCHEMBL15917374 | 0.79 | SIGMAR1 (0.63) | SIGMAR1POLBKDM4ECYP3A4MAPT | |
| SCHEMBL18072554 | 0.78 | SIGMAR1 (0.68) | SIGMAR1POLBKDM4ECYP3A4MAPT | |
| SCHEMBL24457722 | 0.78 | SIGMAR1 (0.63) | SIGMAR1CYP3A4MAPTSMN1; SMN2IDO1 | |
| SCHEMBL10713580 | 0.77 | SIGMAR1 (0.61) | SIGMAR1POLBKDM4ECYP3A4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3409276-B1 | IRE-1A INHIBITORS | FOSUN ORINOVE PHARMATECH INC (CN) | 2020-12-30 | — | — | EP | disclosed |
| EP-2496230-B1 | IRE-1 ALPHA INHIBITORS | FOSUN ORINOVE PHARMATECH INC (CN) | 2020-02-26 | — | — | EP | disclosed |