Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.65 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | IDO1 | P14902 | 2/20 | 0.54 |
| ▸ | THRB | P10828 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | CASR | P41180 | 1/20 | 0.47 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.46 |
| ▸ | SLC18A2 | Q05940 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL143708 | 0.85 | SIGMAR1 (0.65) | SIGMAR1POLBIDO1THRBCYP3A4 | |
| SCHEMBL22899588 | 0.85 | SIGMAR1 (0.65) | SIGMAR1POLBIDO1THRBCYP3A4 | |
| SCHEMBL10939504 | 0.83 | SIGMAR1 (0.53) | SIGMAR1POLBIDO1THRBCYP3A4 | |
| Hydrochloric Acid SCHEMBL1331235 | 0.83 | SIGMAR1 (0.63) | SIGMAR1POLBIDO1THRBCYP3A4 | |
| Bromide SCHEMBL1331742 | 0.83 | SIGMAR1 (0.63) | SIGMAR1POLBIDO1THRBCYP3A4 | |
| Ammonia Solution, Strong SCHEMBL15917374 | 0.83 | SIGMAR1 (0.63) | SIGMAR1POLBIDO1THRBCYP3A4 | |
| SCHEMBL24801993 | 0.82 | SIGMAR1 (0.68) | SIGMAR1POLBIDO1THRBCYP3A4 | |
| SCHEMBL3112736 | 0.82 | SIGMAR1 (0.68) | SIGMAR1POLBIDO1THRBCYP3A4 | |
| SCHEMBL21763643 | 0.81 | SIGMAR1 (0.61) | SIGMAR1POLBIDO1THRBCYP3A4 | |
| SCHEMBL10284202 | 0.81 | SIGMAR1 (0.61) | SIGMAR1POLBIDO1THRBCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3569602-B1 | IMIDAZOPYRAZINE COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF | DONGGUAN ZHENGXING BEITE MEDICINE TECH CO LTD (CN) | 2022-11-23 | — | — | EP | disclosed |
| US-10919899-B2 | Imidazopyrazine compounds, preparation methods and uses thereof | DONGGUAN ZHENXING-BEITE MEDICINE TECHNOLOGY CO., LTD. (CN) | 2021-02-16 | — | — | US | disclosed |
| EP-3569602-A1 | IMIDAZOPYRAZINE COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF | Dongguan Zhengxing-Beite Medicine Technology Co., Ltd. (CN) | 2019-11-20 | — | — | EP | disclosed |
| EP-3150576-B1 | SUBSTITUTED ACETOHYDRAZIDE DERIVATIVES, PREPARATION METHOD THEREFOR AND USE | INST PHARMACOLOGY & TOXICOLOGY ACADEMY MILITARY MEDICAL SCIENCES PLA CHINA (CN) | 2019-07-10 | — | — | EP | disclosed |
| US-10196346-B2 | Substituted acethydrazide derivative, preparation method and use thereof | INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A. CHINA (CN) | 2019-02-05 | — | — | US | disclosed |
| EP-2857393-B1 | N-ARYL UNSATURATED FUSED RING TERTIARY AMINE COMPOUND, PREPARATION METHOD THEREOF AND ANTITUMOR APPLICATION THEREOF | INST PHARMACOLOGY & TOXICOLOGY ACADEMY MILITARY MEDICAL SCIENCES PLA CHINA (CN) | 2018-09-12 | — | — | EP | disclosed |
| EP-2980087-B1 | PRODRUGS OF BICYCLIC SUBSTITUTED PYRIMIDINE TYPE PDE-5 INHIBITORS | XUANZHU PHARMA CO LTD (CN) | 2018-06-06 | — | — | EP | disclosed |
| US-20180134653-A1 | SUBSTITUTED ACETHYDRAZIDE DERIVATIVE, PREPARATION METHOD AND USE THEREOF | INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A. CHINA (CN) | 2018-05-17 | — | — | US | disclosed |
| US-9751884-B2 | N-aryl unsaturated fused ring tertiary amine compounds, preparation method and anti-tumor applications thereof | INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A. CHINA (CN) | 2017-09-05 | — | — | US | disclosed |
| EP-2886540-B1 | BICYCLIC SUBSTITUTED PYRIMIDINE COMPOUNDS | XUANZHU PHARMA CO LTD (CN) | 2017-07-26 | — | — | EP | disclosed |
| US-20150232474-A1 | Bicyclic Substituted Pyrimidine Compounds | Xuanzhu Biopharmaceutical Co., Ltd. (CN) | 2015-08-20 | — | — | US | disclosed |
| EP-2886540-A1 | BICYCLIC SUBSTITUTED PYRIMIDINE COMPOUNDS | Xuanzhu Pharma Co., Ltd. (CN) | 2015-06-24 | — | — | EP | disclosed |
| US-20150141407-A1 | N-Aryl Unsaturated Fused Ring Tertiary Amine Compounds, Preparation Method and Anti-Tumor Applications Thereof | INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A. CHINA (CN) | 2015-05-21 | — | — | US | disclosed |
| EP-2857393-A1 | N-ARYL UNSATURATED FUSED RING TERTIARY AMINE COMPOUND, PREPARATION METHOD THEREOF AND ANTITUMOR APPLICATION THEREOF | Institute Of Pharmacology And Toxicology Academy Of Militaty Medical Sciences P.L.A. (CN) | 2015-04-08 | — | — | EP | disclosed |
| US-7687664-B2 | Carboxylic acid derivative, a salt thereof or an ester of them, and medicament comprising it | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2010-03-30 | — | — | US | disclosed |
| US-7544835-B2 | Carboxylic acid derivative and salt thereof | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2009-06-09 | — | — | US | disclosed |
| US-20040214888-A1 | Carboxylic acid derivative and medicine comprising salt or ester of the same | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2004-10-28 | — | — | US | disclosed |
| US-20040102634-A1 | Carboxylic acid derivative and salt thereof | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2004-05-27 | — | — | US | disclosed |
| EP-1394147-A1 | CARBOXYLIC ACID DERIVATIVE AND MEDICINE COMPRISING SALT OR ESTER OF THE SAME | Eisai Co., Ltd. (JP) | 2004-03-03 | — | — | EP | disclosed |
| EP-1380562-A1 | CARBOXYLIC ACID DERIVATIVE AND SALT THEREOF | Eisai Co., Ltd. (JP) | 2004-01-14 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040102634-A1 | Carboxylic acid derivative and salt thereof | GPR119, IRS1, SLC5A1 | SIGMAR1 59/4885POLB 3622/4885IDO1 1812/4885 |
| US-20150232474-A1 | Bicyclic Substituted Pyrimidine Compounds | DPYD, UMPS, TYMP | SIGMAR1 3896/4885POLB 283/4885IDO1 1342/4885 |
| US-10919899-B2 | Imidazopyrazine compounds, preparation methods and uses thereof | BTK, SYK, ABL1 | SIGMAR1 2543/4885POLB 3229/4885IDO1 1397/4885 |
| US-20150141407-A1 | N-Aryl Unsaturated Fused Ring Tertiary Amine Compounds, Preparation Method and Anti-Tumor Applications Thereof | H1-0, H1-5, H1-3 | SIGMAR1 181/4885POLB 1843/4885IDO1 1377/4885 |
| US-20180134653-A1 | SUBSTITUTED ACETHYDRAZIDE DERIVATIVE, PREPARATION METHOD AND USE THEREOF | HIF1AN, HIF1A, EGLN3 | SIGMAR1 1851/4885POLB 2896/4885IDO1 585/4885 |
| US-10196346-B2 | Substituted acethydrazide derivative, preparation method and use thereof | HIF1AN, HIF1A, EGLN3 | SIGMAR1 1851/4885POLB 2896/4885IDO1 585/4885 |
| US-20040214888-A1 | Carboxylic acid derivative and medicine comprising salt or ester of the same | GPR119, NR3C1, INSR | SIGMAR1 208/4885POLB 2625/4885IDO1 2695/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.