Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.52 |
| ▸ | GAA | P10253 | 7/20 | 0.52 |
| ▸ | RAB9A | P51151 | 7/20 | 0.52 |
| ▸ | NPC1 | O15118 | 6/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | KDM6B | O15054 | 1/20 | 0.43 |
| ▸ | TET3 | O43151 | 1/20 | 0.43 |
| ▸ | KDM4A | O75164 | 1/20 | 0.43 |
| ▸ | KDM4B | O94953 | 1/20 | 0.43 |
| ▸ | KDM5A | P29375 | 1/20 | 0.43 |
| ▸ | KDM5C | P41229 | 1/20 | 0.43 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20101098 | 0.79 | MAPT (0.73) | MAPTGAARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL15267189 | 0.78 | KDM4E (0.58) | MAPTGAARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL31213370 | 0.76 | MAPT (0.68) | MAPTGAARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL1973299 | 0.74 | RAB9A (0.59) | MAPTGAARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL4926318 | 0.73 | KDM4E (0.72) | MAPTGAARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL20101080 | 0.73 | KDM4E (0.72) | MAPTGAARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL18193552 | 0.72 | ATM (0.63) | MAPTGAARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL7831618 | 0.71 | RAB9A (0.56) | MAPTGAARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL11335426 | 0.71 | RAB9A (0.42) | MAPTGAARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL11335430 | 0.71 | RAB9A (0.42) | MAPTGAARAB9ANPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3613733-A1 | NOVEL CRYSTALLINE SOLID COMPOUND OF 3-PHENYL-4-PROPYL-1-(PYRIDIN-2-YL)-1H-PYRAZOL-5-OL HYDROCHLORIDE | Aptabio Therapeutics Inc. (KR) | 2020-02-26 | — | — | EP | disclosed |