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Sugi Predict / Compounds / SCHEMBL21765647

SCHEMBL21765647

SCHEMBL21765647

COC(=O)C(C(=O)OC)C(=O)C1(n2cccc2-c2ccc(OC)cc2)CCCCC1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ FAAH O00519 1/20 0.38
▸ TRPV1 Q8NER1 1/20 0.38
▸ CTSK P43235 3/20 0.37
▸ P2RX3 P56373 1/20 0.37
▸ MEN1 O00255 2/20 0.36
▸ KMT2A Q03164 2/20 0.36
▸ MAOA P21397 1/20 0.36
▸ ACHE P22303 1/20 0.36
▸ ALDH1A1 P00352 5/20 0.36
▸ HPGD P15428 2/20 0.36
▸ TDP1 Q9NUW8 1/20 0.36
▸ SMN1; SMN2 Q16637 2/20 0.34
▸ KDM4E B2RXH2 2/20 0.34
▸ NPC1 O15118 1/20 0.34
▸ TP53 P04637 1/20 0.34
▸ TSHR P16473 1/20 0.34
▸ RAB9A P51151 1/20 0.34
▸ HSD17B10 Q99714 1/20 0.34
▸ JAK1 P23458 2/20 0.34
▸ IKBKB O14920 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21765532 0.99 FAAH (0.36) FAAHTRPV1CTSKP2RX3MEN1
SCHEMBL21747378 0.90 FAAH (0.39) FAAHTRPV1CTSKP2RX3MEN1
SCHEMBL21765637 0.90 KMT2A (0.37) FAAHTRPV1CTSKMEN1KMT2A
SCHEMBL21765755 0.89 SLC6A4 (0.34) FAAHKDM4ETSHRHSD17B10GSK3B
SCHEMBL21765773 0.89 ACHE (0.36) TRPV1ACHEKDM4ETP53
SCHEMBL21765764 0.89 EGLN1 (0.33) ALDH1A1TDP1HTT
SCHEMBL21747267 0.89 ALDH1A1 (0.37) FAAHTRPV1CTSKP2RX3MEN1
SCHEMBL21765817 0.89 KMT2A (0.37) MEN1KMT2AACHEALDH1A1KDM4E
SCHEMBL21765631 0.88 ACHE (0.36) TRPV1ACHEKDM4ETP53
SCHEMBL21765758 0.88 SLC6A4 (0.35) FAAHKDM4ETSHRHSD17B10GSK3B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11970495-B2 Indolizine derivatives and their application in medicine KIND PHARMACEUTICAL (CN) 2024-04-30 — — US disclosed
US-11945817-B2 Indolizine derivatives and their application in medicine KIND PHARMACEUTICAL (CN) 2024-04-02 — — US disclosed
US-20230257379-A1 INDOLIZINE DERIVATIVES AND THEIR APPLICATION IN MEDICINE KIND PHARMACEUTICAL (CN) 2023-08-17 — — US disclosed
US-20230257379-A1 INDOLIZINE DERIVATIVES AND THEIR APPLICATION IN MEDICINE KIND PHARMACEUTICAL (CN) 2023-08-17 — — US disclosed
US-20230257379-A1 INDOLIZINE DERIVATIVES AND THEIR APPLICATION IN MEDICINE KIND PHARMACEUTICAL (CN) 2023-08-17 — — US disclosed
US-20230242527-A1 INDOLIZINE DERIVATIVES AND THEIR APPLICATION IN MEDICINE KIND PHARMACEUTICAL (CN) 2023-08-03 — — US disclosed
US-20230242527-A1 INDOLIZINE DERIVATIVES AND THEIR APPLICATION IN MEDICINE KIND PHARMACEUTICAL (CN) 2023-08-03 — — US disclosed
US-20230242527-A1 INDOLIZINE DERIVATIVES AND THEIR APPLICATION IN MEDICINE KIND PHARMACEUTICAL (CN) 2023-08-03 — — US disclosed
US-11655249-B2 Indolizine derivatives and their application in medicine KIND PHARMACEUTICAL (CN) 2023-05-23 — — US disclosed
US-11655249-B2 Indolizine derivatives and their application in medicine KIND PHARMACEUTICAL (CN) 2023-05-23 — — US disclosed
US-11655249-B2 Indolizine derivatives and their application in medicine KIND PHARMACEUTICAL (CN) 2023-05-23 — — US disclosed
EP-3613742-B1 INDOLIZINE DERIVATIVES AND APPLICATION THEREOF IN MEDICINE KIND PHARMACEUTICAL (CN) 2022-12-07 — — EP disclosed
US-20210253570-A1 INDOLIZINE DERIVATIVES AND THEIR APPLICATION IN MEDICINE KIND PHARMACEUTICAL (CN) 2021-08-19 — — US disclosed
CN-113004271-A Indolizine derivative and application thereof in medicine 杭州安道药业有限公司 2021-06-22 — — CN disclosed
US-11021478-B2 Indolizine derivatives and their application in medicine KIND PHARMACEUTICAL (CN) 2021-06-01 — — US disclosed
CN-108484598-B Indolizine derivative and application thereof in medicine 杭州安道药业有限公司 2021-03-02 — — CN disclosed
US-20200165242-A1 INDOLIZINE DERIVATIVES AND THEIR APPLICATION IN MEDICINE KIND PHARMACEUTICAL (CN) 2020-05-28 — — US disclosed
EP-3613742-A1 INDOLIZINE DERIVATIVES AND APPLICATION THEREOF IN MEDICINE Kind Pharmaceutical (CN) 2020-02-26 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230257379-A1 INDOLIZINE DERIVATIVES AND THEIR APPLICATION IN MEDICINE INMT, IDO1, IDO2 FAAH 2999/4885TRPV1 980/4885CTSK 3651/4885
US-11021478-B2 Indolizine derivatives and their application in medicine INMT, IDO1, IDO2 FAAH 2999/4885TRPV1 980/4885CTSK 3651/4885
US-11970495-B2 Indolizine derivatives and their application in medicine INMT, IDO1, IDO2 FAAH 2999/4885TRPV1 980/4885CTSK 3651/4885
US-20230242527-A1 INDOLIZINE DERIVATIVES AND THEIR APPLICATION IN MEDICINE INMT, IDO1, IDO2 FAAH 2999/4885TRPV1 980/4885CTSK 3651/4885
US-11945817-B2 Indolizine derivatives and their application in medicine INMT, IDO1, IDO2 FAAH 2999/4885TRPV1 980/4885CTSK 3651/4885
US-20210253570-A1 INDOLIZINE DERIVATIVES AND THEIR APPLICATION IN MEDICINE INMT, IDO1, IDO2 FAAH 2999/4885TRPV1 980/4885CTSK 3651/4885
US-11655249-B2 Indolizine derivatives and their application in medicine INMT, IDO1, IDO2 FAAH 2999/4885TRPV1 980/4885CTSK 3651/4885
US-20200165242-A1 INDOLIZINE DERIVATIVES AND THEIR APPLICATION IN MEDICINE INMT, IDO1, IDO2 FAAH 2999/4885TRPV1 980/4885CTSK 3651/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.