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SCHEMBL21765779

SCHEMBL21765779

COC(=O)C(C(=O)OC)C(=O)C1(n2ccc(-c3ccccc3)c2)CCCCC1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 3/20 0.37
▸ KMT2A Q03164 2/20 0.37
▸ MEN1 O00255 1/20 0.37
▸ LMNA P02545 1/20 0.37
▸ ACHE P22303 1/20 0.36
▸ CYP26A1 O43174 1/20 0.36
▸ SLC6A2 P23975 1/20 0.34
▸ SLC6A4 P31645 1/20 0.34
▸ SLC6A3 Q01959 1/20 0.34
▸ HDAC1 Q13547 4/20 0.34
▸ HDAC6 Q9UBN7 4/20 0.34
▸ OPRM1 P35372 1/20 0.34
▸ OPRK1 P41145 1/20 0.34
▸ OPRL1 P41146 1/20 0.34
▸ CYP3A4 P08684 3/20 0.33
▸ USP2 O75604 2/20 0.33
▸ CYP1A2 P05177 2/20 0.33
▸ HSD17B10 Q99714 2/20 0.33
▸ CYP2C9 P11712 1/20 0.33
▸ ALOX15 P16050 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21765788 0.99 ACHE (0.37) ALDH1A1KMT2AMEN1LMNAACHE
SCHEMBL21765552 0.96 ACHE (0.37) ALDH1A1KMT2AMEN1LMNAACHE
SCHEMBL21765544 0.88 ACHE (0.39) KMT2AMEN1ACHESLC6A2SLC6A4
SCHEMBL21765536 0.88 ITGB1 (0.33) ALDH1A1KMT2AMEN1SLC6A4SLC6A3
SCHEMBL21765802 0.88 ACHE (0.39) ALDH1A1KMT2AMEN1LMNAACHE
SCHEMBL21747292 0.86 MME (0.36) ALDH1A1KMT2AMEN1SLC6A2SLC6A4
SCHEMBL21747416 0.85 ITGB1 (0.35) ALDH1A1MAPK1ITGB1ITGA4
SCHEMBL21747268 0.82 FASN (0.34) ALDH1A1MAPK1ITGB1ITGA4
SCHEMBL21747335 0.79 AKR1C1 (0.39) ALDH1A1KMT2AMEN1LMNASLC6A2
SCHEMBL21765797 0.79 ALDH1A1 (0.33) ALDH1A1KMT2AMEN1LMNAOPRM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11970495-B2 Indolizine derivatives and their application in medicine KIND PHARMACEUTICAL (CN) 2024-04-30 — — US disclosed
US-11945817-B2 Indolizine derivatives and their application in medicine KIND PHARMACEUTICAL (CN) 2024-04-02 — — US disclosed
US-20230257379-A1 INDOLIZINE DERIVATIVES AND THEIR APPLICATION IN MEDICINE KIND PHARMACEUTICAL (CN) 2023-08-17 — — US disclosed
US-20230257379-A1 INDOLIZINE DERIVATIVES AND THEIR APPLICATION IN MEDICINE KIND PHARMACEUTICAL (CN) 2023-08-17 — — US disclosed
US-20230242527-A1 INDOLIZINE DERIVATIVES AND THEIR APPLICATION IN MEDICINE KIND PHARMACEUTICAL (CN) 2023-08-03 — — US disclosed
US-20230242527-A1 INDOLIZINE DERIVATIVES AND THEIR APPLICATION IN MEDICINE KIND PHARMACEUTICAL (CN) 2023-08-03 — — US disclosed
US-11655249-B2 Indolizine derivatives and their application in medicine KIND PHARMACEUTICAL (CN) 2023-05-23 — — US disclosed
US-11655249-B2 Indolizine derivatives and their application in medicine KIND PHARMACEUTICAL (CN) 2023-05-23 — — US disclosed
EP-3613742-B1 INDOLIZINE DERIVATIVES AND APPLICATION THEREOF IN MEDICINE KIND PHARMACEUTICAL (CN) 2022-12-07 — — EP disclosed
US-20210253570-A1 INDOLIZINE DERIVATIVES AND THEIR APPLICATION IN MEDICINE KIND PHARMACEUTICAL (CN) 2021-08-19 — — US disclosed
CN-113004271-A Indolizine derivative and application thereof in medicine 杭州安道药业有限公司 2021-06-22 — — CN disclosed
US-11021478-B2 Indolizine derivatives and their application in medicine KIND PHARMACEUTICAL (CN) 2021-06-01 — — US disclosed
CN-108484598-B Indolizine derivative and application thereof in medicine 杭州安道药业有限公司 2021-03-02 — — CN disclosed
US-20200165242-A1 INDOLIZINE DERIVATIVES AND THEIR APPLICATION IN MEDICINE KIND PHARMACEUTICAL (CN) 2020-05-28 — — US disclosed
EP-3613742-A1 INDOLIZINE DERIVATIVES AND APPLICATION THEREOF IN MEDICINE Kind Pharmaceutical (CN) 2020-02-26 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230257379-A1 INDOLIZINE DERIVATIVES AND THEIR APPLICATION IN MEDICINE INMT, IDO1, IDO2 ALDH1A1 1770/4885KMT2A 2472/4885MEN1 1102/4885
US-11021478-B2 Indolizine derivatives and their application in medicine INMT, IDO1, IDO2 ALDH1A1 1770/4885KMT2A 2472/4885MEN1 1102/4885
US-11970495-B2 Indolizine derivatives and their application in medicine INMT, IDO1, IDO2 ALDH1A1 1770/4885KMT2A 2472/4885MEN1 1102/4885
US-20230242527-A1 INDOLIZINE DERIVATIVES AND THEIR APPLICATION IN MEDICINE INMT, IDO1, IDO2 ALDH1A1 1770/4885KMT2A 2472/4885MEN1 1102/4885
US-11945817-B2 Indolizine derivatives and their application in medicine INMT, IDO1, IDO2 ALDH1A1 1770/4885KMT2A 2472/4885MEN1 1102/4885
US-20210253570-A1 INDOLIZINE DERIVATIVES AND THEIR APPLICATION IN MEDICINE INMT, IDO1, IDO2 ALDH1A1 1770/4885KMT2A 2472/4885MEN1 1102/4885
US-11655249-B2 Indolizine derivatives and their application in medicine INMT, IDO1, IDO2 ALDH1A1 1770/4885KMT2A 2472/4885MEN1 1102/4885
US-20200165242-A1 INDOLIZINE DERIVATIVES AND THEIR APPLICATION IN MEDICINE INMT, IDO1, IDO2 ALDH1A1 1770/4885KMT2A 2472/4885MEN1 1102/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.