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SCHEMBL21765788

SCHEMBL21765788

COC(=O)C(C(=O)OC)C(=O)C1(n2ccc(-c3ccccc3)c2)CCCC1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ACHE P22303 1/20 0.37
▸ CYP26A1 O43174 1/20 0.37
▸ ALDH1A1 P00352 4/20 0.35
▸ KMT2A Q03164 2/20 0.35
▸ MEN1 O00255 1/20 0.35
▸ LMNA P02545 1/20 0.35
▸ OPRM1 P35372 1/20 0.34
▸ OPRK1 P41145 1/20 0.34
▸ OPRL1 P41146 1/20 0.34
▸ HDAC1 Q13547 4/20 0.34
▸ HDAC6 Q9UBN7 4/20 0.34
▸ USP2 O75604 3/20 0.34
▸ CYP3A4 P08684 3/20 0.34
▸ HSD17B10 Q99714 3/20 0.34
▸ CYP1A2 P05177 2/20 0.34
▸ ATM Q13315 1/20 0.34
▸ CYP2C9 P11712 1/20 0.34
▸ ALOX15 P16050 1/20 0.34
▸ MAPK1 P28482 1/20 0.34
▸ HIF1A Q16665 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21765779 0.99 ALDH1A1 (0.37) ACHECYP26A1ALDH1A1KMT2AMEN1
SCHEMBL21765552 0.98 ACHE (0.37) ACHECYP26A1ALDH1A1KMT2AMEN1
SCHEMBL21765536 0.87 ITGB1 (0.33) ALDH1A1KMT2AMEN1HSD17B10CYP1A2
SCHEMBL21765802 0.87 ACHE (0.39) ACHEALDH1A1KMT2AMEN1LMNA
SCHEMBL21765544 0.87 ACHE (0.39) ACHEKMT2AMEN1KDM4E
SCHEMBL21747416 0.86 ITGB1 (0.35) ALDH1A1MAPK1KDM4E
SCHEMBL21747292 0.85 MME (0.36) ALDH1A1KMT2AMEN1KDM4E
SCHEMBL21747268 0.83 FASN (0.34) ALDH1A1MAPK1KDM4E
SCHEMBL21747384 0.79 AKR1C1 (0.40) ALDH1A1KMT2AMEN1LMNAUSP2
SCHEMBL21765797 0.77 ALDH1A1 (0.33) ALDH1A1KMT2AMEN1LMNAOPRM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11970495-B2 Indolizine derivatives and their application in medicine KIND PHARMACEUTICAL (CN) 2024-04-30 — — US disclosed
US-11945817-B2 Indolizine derivatives and their application in medicine KIND PHARMACEUTICAL (CN) 2024-04-02 — — US disclosed
US-20230257379-A1 INDOLIZINE DERIVATIVES AND THEIR APPLICATION IN MEDICINE KIND PHARMACEUTICAL (CN) 2023-08-17 — — US disclosed
US-20230257379-A1 INDOLIZINE DERIVATIVES AND THEIR APPLICATION IN MEDICINE KIND PHARMACEUTICAL (CN) 2023-08-17 — — US disclosed
US-20230242527-A1 INDOLIZINE DERIVATIVES AND THEIR APPLICATION IN MEDICINE KIND PHARMACEUTICAL (CN) 2023-08-03 — — US disclosed
US-20230242527-A1 INDOLIZINE DERIVATIVES AND THEIR APPLICATION IN MEDICINE KIND PHARMACEUTICAL (CN) 2023-08-03 — — US disclosed
US-11655249-B2 Indolizine derivatives and their application in medicine KIND PHARMACEUTICAL (CN) 2023-05-23 — — US disclosed
US-11655249-B2 Indolizine derivatives and their application in medicine KIND PHARMACEUTICAL (CN) 2023-05-23 — — US disclosed
EP-3613742-B1 INDOLIZINE DERIVATIVES AND APPLICATION THEREOF IN MEDICINE KIND PHARMACEUTICAL (CN) 2022-12-07 — — EP disclosed
US-20210253570-A1 INDOLIZINE DERIVATIVES AND THEIR APPLICATION IN MEDICINE KIND PHARMACEUTICAL (CN) 2021-08-19 — — US disclosed
CN-113004271-A Indolizine derivative and application thereof in medicine 杭州安道药业有限公司 2021-06-22 — — CN disclosed
US-11021478-B2 Indolizine derivatives and their application in medicine KIND PHARMACEUTICAL (CN) 2021-06-01 — — US disclosed
CN-108484598-B Indolizine derivative and application thereof in medicine 杭州安道药业有限公司 2021-03-02 — — CN disclosed
US-20200165242-A1 INDOLIZINE DERIVATIVES AND THEIR APPLICATION IN MEDICINE KIND PHARMACEUTICAL (CN) 2020-05-28 — — US disclosed
EP-3613742-A1 INDOLIZINE DERIVATIVES AND APPLICATION THEREOF IN MEDICINE Kind Pharmaceutical (CN) 2020-02-26 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230257379-A1 INDOLIZINE DERIVATIVES AND THEIR APPLICATION IN MEDICINE INMT, IDO1, IDO2 ACHE 992/4885CYP26A1 478/4885ALDH1A1 1770/4885
US-11021478-B2 Indolizine derivatives and their application in medicine INMT, IDO1, IDO2 ACHE 992/4885CYP26A1 478/4885ALDH1A1 1770/4885
US-11970495-B2 Indolizine derivatives and their application in medicine INMT, IDO1, IDO2 ACHE 992/4885CYP26A1 478/4885ALDH1A1 1770/4885
US-20230242527-A1 INDOLIZINE DERIVATIVES AND THEIR APPLICATION IN MEDICINE INMT, IDO1, IDO2 ACHE 992/4885CYP26A1 478/4885ALDH1A1 1770/4885
US-11945817-B2 Indolizine derivatives and their application in medicine INMT, IDO1, IDO2 ACHE 992/4885CYP26A1 478/4885ALDH1A1 1770/4885
US-20210253570-A1 INDOLIZINE DERIVATIVES AND THEIR APPLICATION IN MEDICINE INMT, IDO1, IDO2 ACHE 992/4885CYP26A1 478/4885ALDH1A1 1770/4885
US-11655249-B2 Indolizine derivatives and their application in medicine INMT, IDO1, IDO2 ACHE 992/4885CYP26A1 478/4885ALDH1A1 1770/4885
US-20200165242-A1 INDOLIZINE DERIVATIVES AND THEIR APPLICATION IN MEDICINE INMT, IDO1, IDO2 ACHE 992/4885CYP26A1 478/4885ALDH1A1 1770/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.