Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.52 |
| ▸ | PRKACA | P17612 | 3/20 | 0.50 |
| ▸ | PRKACG | P22612 | 3/20 | 0.50 |
| ▸ | PRKACB | P22694 | 3/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.49 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.46 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | BCHE | P06276 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | BACE1 | P56817 | 1/20 | 0.44 |
| ▸ | KDM1A | O60341 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30056809 | 1.00 | DRD2 (0.52) | DRD2PRKACAPRKACGPRKACBSIGMAR1 | |
| Hydrochloric Acid SCHEMBL21752840 | 0.98 | DRD2 (0.51) | DRD2PRKACAPRKACGPRKACBSIGMAR1 | |
| Hydrochloric Acid SCHEMBL30921645 | 0.98 | DRD2 (0.51) | DRD2PRKACAPRKACGPRKACBSIGMAR1 | |
| SCHEMBL17967991 | 0.91 | DRD2 (0.58) | DRD2SIGMAR1OPRM1CHRM2CHRM3 | |
| Hydrochloric Acid SCHEMBL21752824 | 0.89 | DRD2 (0.57) | DRD2SIGMAR1OPRM1OPRK1OPRD1 | |
| Hydrochloric Acid SCHEMBL17557617 | 0.89 | DRD2 (0.57) | DRD2SIGMAR1OPRM1OPRK1OPRD1 | |
| Hydrochloric Acid SCHEMBL30056142 | 0.89 | DRD2 (0.57) | DRD2SIGMAR1OPRM1OPRK1OPRD1 | |
| SCHEMBL21765981 | 0.87 | OPRM1 (0.51) | DRD2SIGMAR1OPRM1OPRK1OPRD1 | |
| Hydrochloric Acid SCHEMBL26128904 | 0.86 | OPRM1 (0.50) | DRD2SIGMAR1OPRM1OPRK1OPRD1 | |
| SCHEMBL25456999 | 0.82 | ACHE (0.53) | DRD2SIGMAR1OPRM1OPRK1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3840832-B1 | IMIDAZO[1,2-B]PYRIDAZINES AS TRK INHIBITORS | BENEVOLENTAI BIO LTD (GB) | 2023-10-11 | — | — | EP | disclosed |
| US-20230149398-A1 | TOPICAL PHARMACEUTICAL COMPOSITIONS COMPRISING IMIDAZO[1,2-B]PYRIDAZINE COMPOUNDS | BENEVOLENTAI BIO LIMITED (GB) | 2023-05-18 | — | — | US | disclosed |
| US-20230149398-A1 | TOPICAL PHARMACEUTICAL COMPOSITIONS COMPRISING IMIDAZO[1,2-B]PYRIDAZINE COMPOUNDS | BENEVOLENTAI BIO LIMITED (GB) | 2023-05-18 | — | — | US | disclosed |
| CN-115297863-A | Topical pharmaceutical compositions comprising imidazo [1,2-b ] pyridazine compounds | 博善人工智能生物科技有限公司 | 2022-11-04 | — | — | CN | disclosed |
| US-20210253572-A1 | IMIDAZO[1,2-B]PYRIDAZINES AS TRK INHIBITORS | BenevolentAl Bio Limited (GB) | 2021-08-19 | — | — | US | disclosed |
| WO-2021148805-A1 | TOPICAL PHARMACEUTICAL COMPOSITIONS COMPRISING IMIDAZO[1,2-B]PYRIDAZINE COMPOUNDS | BENEVOLENTAI BIO LIMITED (GB) | 2021-07-29 | — | — | WO | disclosed |
| WO-2020039209-A1 | IMIDAZO[1,2-B]PYRIDAZINES AS TRK INHIBITORS | BENEVOLENTAI BIO LIMITED (GB) | 2020-02-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230149398-A1 | TOPICAL PHARMACEUTICAL COMPOSITIONS COMPRISING IMIDAZO[1,2-B]PYRIDAZINE COMPOUNDS | TNK2, TNIK, TNK1 | DRD2 4507/4885PRKACA 63/4885PRKACG 77/4885 |
| US-20210253572-A1 | IMIDAZO[1,2-B]PYRIDAZINES AS TRK INHIBITORS | MUSK, TPM3, CSNK1A1 | DRD2 3830/4885PRKACA 192/4885PRKACG 252/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.