Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
| ▸ | PRKACA | P17612 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | CDK8 | P49336 | 1/20 | 0.35 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.35 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.35 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.35 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21747386 | 0.76 | MEN1 (0.44) | PCSK9KMT2AMEN1NPSR1ALDH1A1 | |
| SCHEMBL21747345 | 0.73 | KMT2A (0.39) | PCSK9KMT2AMEN1NPSR1ALDH1A1 | |
| SCHEMBL25544035 | 0.71 | MEN1 (0.40) | PCSK9KMT2AMEN1NPSR1TSHR | |
| SCHEMBL27412445 | 0.71 | PCSK9 (0.41) | PCSK9KMT2AMEN1NPSR1CHEK1 | |
| Biphenyl SCHEMBL27538626 | 0.69 | ALDH1A1 (0.47) | ALDH1A1MAPTLMNAHTTCYP2C9 | |
| SCHEMBL21765754 | 0.69 | KMT2A (0.45) | KMT2AMEN1NPSR1ALDH1A1KDM4E | |
| SCHEMBL6445284 | 0.67 | PCSK9 (0.41) | PCSK9CHEK1MAP4K4CSF1RPRKACA | |
| SCHEMBL6444709 | 0.63 | PCSK9 (0.73) | PCSK9KMT2ANPSR1CHEK1MAP4K4 | |
| Formamide SCHEMBL28739639 | 0.62 | ATM (0.52) | PCSK9KMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL8634800 | 0.62 | PCSK9 (0.44) | PCSK9ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3613742-A1 | INDOLIZINE DERIVATIVES AND APPLICATION THEREOF IN MEDICINE | Kind Pharmaceutical (CN) | 2020-02-26 | — | — | EP | disclosed |