Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | HTRA1 | Q92743 | 1/20 | 0.37 |
| ▸ | UCHL1 | P09936 | 3/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.34 |
| ▸ | RORC | P51449 | 1/20 | 0.34 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.34 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.34 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
| ▸ | F13A1 | P00488 | 1/20 | 0.33 |
| ▸ | TGM2 | P21980 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21637229 | 1.00 | HSD11B1 (0.38) | HSD11B1HTRA1UCHL1CYP1A2POLB | |
| SCHEMBL31510934 | 0.88 | CYP1A2 (0.39) | HSD11B1HTRA1UCHL1CYP1A2POLB | |
| SCHEMBL5963539 | 0.82 | HSD11B1 (0.36) | HSD11B1HTRA1UCHL1CYP1A2POLB | |
| SCHEMBL22715472 | 0.81 | EPHX2 (0.43) | UCHL1MEN1KMT2ANR1H2NR1H3 | |
| SCHEMBL31569184 | 0.81 | PTPN1 (0.47) | UCHL1NAMPTMEN1KMT2APTPN1 | |
| SCHEMBL26985052 | 0.81 | PTPN1 (0.39) | UCHL1NAMPTMEN1KMT2ARORC | |
| SCHEMBL23975412 | 0.80 | UCHL1 (0.44) | UCHL1POLBUSP30MEN1KMT2A | |
| SCHEMBL30954452 | 0.80 | UCHL1 (0.39) | UCHL1POLBMEN1KMT2ANR1H2 | |
| SCHEMBL31510905 | 0.80 | EPHX2 (0.51) | HSD11B1UCHL1POLBUSP30MEN1 | |
| SCHEMBL30537463 | 0.80 | EPHX2 (0.51) | HSD11B1UCHL1POLBUSP30MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020039209-A1 | IMIDAZO[1,2-B]PYRIDAZINES AS TRK INHIBITORS | BENEVOLENTAI BIO LIMITED (GB) | 2020-02-27 | — | — | WO | disclosed |