Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | HTRA1 | Q92743 | 1/20 | 0.37 |
| ▸ | UCHL1 | P09936 | 3/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.34 |
| ▸ | RORC | P51449 | 1/20 | 0.34 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.34 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.34 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
| ▸ | F13A1 | P00488 | 1/20 | 0.33 |
| ▸ | TGM2 | P21980 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21765940 | 1.00 | HSD11B1 (0.38) | HSD11B1HTRA1UCHL1CYP1A2POLB | |
| SCHEMBL31510934 | 0.88 | CYP1A2 (0.39) | HSD11B1HTRA1UCHL1CYP1A2POLB | |
| SCHEMBL5963539 | 0.82 | HSD11B1 (0.36) | HSD11B1HTRA1UCHL1CYP1A2POLB | |
| SCHEMBL22715472 | 0.81 | EPHX2 (0.43) | UCHL1MEN1KMT2ANR1H2NR1H3 | |
| SCHEMBL31569184 | 0.81 | PTPN1 (0.47) | UCHL1NAMPTMEN1KMT2APTPN1 | |
| SCHEMBL26985052 | 0.81 | PTPN1 (0.39) | UCHL1NAMPTMEN1KMT2ARORC | |
| SCHEMBL23975412 | 0.80 | UCHL1 (0.44) | UCHL1POLBUSP30MEN1KMT2A | |
| SCHEMBL30954452 | 0.80 | UCHL1 (0.39) | UCHL1POLBMEN1KMT2ANR1H2 | |
| SCHEMBL31510905 | 0.80 | EPHX2 (0.51) | HSD11B1UCHL1POLBUSP30MEN1 | |
| SCHEMBL30537463 | 0.80 | EPHX2 (0.51) | HSD11B1UCHL1POLBUSP30MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250276966-A1 | Nitrogen-Linked Benzisoxazole Sulfonamide Derivatives | PFIZER (US) | 2025-09-04 | — | — | US | disclosed |
| US-20250122183-A1 | Nitrogen-Linked Benzisoxazole Sulfonamide Derivatives | PFIZER (US) | 2025-04-17 | — | — | US | disclosed |
| WO-2025074249-A1 | NITROGEN-LINKED BENZISOXAZOLE SULFONAMIDE DERIVATIVES FOR THE TREATMENT OF CANCER | PFIZER INC. (US) | 2025-04-10 | — | — | WO | disclosed |
| EP-3840832-B1 | IMIDAZO[1,2-B]PYRIDAZINES AS TRK INHIBITORS | BENEVOLENTAI BIO LTD (GB) | 2023-10-11 | — | — | EP | disclosed |
| EP-3840832-B1 | IMIDAZO[1,2-B]PYRIDAZINES AS TRK INHIBITORS | BENEVOLENTAI BIO LTD (GB) | 2023-10-11 | — | — | EP | disclosed |
| US-20230149398-A1 | TOPICAL PHARMACEUTICAL COMPOSITIONS COMPRISING IMIDAZO[1,2-B]PYRIDAZINE COMPOUNDS | BENEVOLENTAI BIO LIMITED (GB) | 2023-05-18 | — | — | US | disclosed |
| US-20230149398-A1 | TOPICAL PHARMACEUTICAL COMPOSITIONS COMPRISING IMIDAZO[1,2-B]PYRIDAZINE COMPOUNDS | BENEVOLENTAI BIO LIMITED (GB) | 2023-05-18 | — | — | US | disclosed |
| US-20230149398-A1 | TOPICAL PHARMACEUTICAL COMPOSITIONS COMPRISING IMIDAZO[1,2-B]PYRIDAZINE COMPOUNDS | BENEVOLENTAI BIO LIMITED (GB) | 2023-05-18 | — | — | US | disclosed |
| US-20230112039-A1 | PHARMACEUTICAL COMPOSITIONS AND THEIR USES | BENEVOLENTAI BIO LIMITED (GB) | 2023-04-13 | — | — | US | disclosed |
| EP-4093404-A1 | TOPICAL PHARMACEUTICAL COMPOSITIONS COMPRISING IMIDAZO[1,2-B]PYRIDAZINE COMPOUNDS | BenevolentAI Bio Limited (GB) | 2022-11-30 | — | — | EP | disclosed |
| WO-2022234287-A1 | IMIDAZOPYRIDAZINE DERIVATIVES USEFUL AS TRK INHIBITORS | BENEVOLENTAI BIO LIMITED (GB) | 2022-11-10 | — | — | WO | disclosed |
| WO-2022234287-A1 | IMIDAZOPYRIDAZINE DERIVATIVES USEFUL AS TRK INHIBITORS | BENEVOLENTAI BIO LIMITED (GB) | 2022-11-10 | — | — | WO | disclosed |
| CN-115315254-A | Pharmaceutical composition and use thereof | 博善人工智能生物科技有限公司 | 2022-11-08 | — | — | CN | disclosed |
| CN-115297863-A | Topical pharmaceutical compositions comprising imidazo [1,2-b ] pyridazine compounds | 博善人工智能生物科技有限公司 | 2022-11-04 | — | — | CN | disclosed |
| EP-3823972-B1 | IMIDAZO[1,2-B]PYRIDAZINE DERIVATIVES AS TRK INHIBITORS | BENEVOLENTAI BIO LTD (GB) | 2022-09-07 | — | — | EP | disclosed |
| US-20210277008-A1 | IMIDAZO[1,2-B]PYRIDAZINE DERIVATIVES AS TRK INHIBITORS | BENEVOLENTAI BIO LIMITED (GB) | 2021-09-09 | — | — | US | disclosed |
| US-20210253572-A1 | IMIDAZO[1,2-B]PYRIDAZINES AS TRK INHIBITORS | BenevolentAl Bio Limited (GB) | 2021-08-19 | — | — | US | disclosed |
| WO-2021148805-A1 | TOPICAL PHARMACEUTICAL COMPOSITIONS COMPRISING IMIDAZO[1,2-B]PYRIDAZINE COMPOUNDS | BENEVOLENTAI BIO LIMITED (GB) | 2021-07-29 | — | — | WO | disclosed |
| WO-2020039209-A1 | IMIDAZO[1,2-B]PYRIDAZINES AS TRK INHIBITORS | BENEVOLENTAI BIO LIMITED (GB) | 2020-02-27 | — | — | WO | disclosed |
| WO-2020016594-A1 | IMIDAZO[1,2-B]PYRIDAZINE DERIVATIVES AS TRK INHIBITORS | BENEVOLENTAI BIO LIMITED (GB) | 2020-01-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230112039-A1 | PHARMACEUTICAL COMPOSITIONS AND THEIR USES | TNK2, DMPK, TPM3 | HSD11B1 2092/4885HTRA1 1280/4885UCHL1 3111/4885 |
| US-20250122183-A1 | Nitrogen-Linked Benzisoxazole Sulfonamide Derivatives | CCNI, MKI67, CCNA1 | HSD11B1 4240/4885HTRA1 1449/4885UCHL1 2401/4885 |
| US-20250276966-A1 | Nitrogen-Linked Benzisoxazole Sulfonamide Derivatives | CCNI, MKI67, CCNA1 | HSD11B1 4304/4885HTRA1 1472/4885UCHL1 2452/4885 |
| US-20210277008-A1 | IMIDAZO[1,2-B]PYRIDAZINE DERIVATIVES AS TRK INHIBITORS | MUSK, TPM3, NTRK1 | HSD11B1 3416/4885HTRA1 2701/4885UCHL1 3419/4885 |
| US-20230149398-A1 | TOPICAL PHARMACEUTICAL COMPOSITIONS COMPRISING IMIDAZO[1,2-B]PYRIDAZINE COMPOUNDS | TNK2, TNIK, TNK1 | HSD11B1 2310/4885HTRA1 1789/4885UCHL1 3931/4885 |
| US-20210253572-A1 | IMIDAZO[1,2-B]PYRIDAZINES AS TRK INHIBITORS | MUSK, TPM3, CSNK1A1 | HSD11B1 2880/4885HTRA1 2605/4885UCHL1 3293/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.