Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.72 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.72 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.72 |
| ▸ | TSHR | P16473 | 1/20 | 0.72 |
| ▸ | HPGD | P15428 | 1/20 | 0.71 |
| ▸ | LMNA | P02545 | 2/20 | 0.69 |
| ▸ | PKM | P14618 | 2/20 | 0.69 |
| ▸ | TP53 | P04637 | 1/20 | 0.68 |
| ▸ | POLB | P06746 | 1/20 | 0.68 |
| ▸ | MAPT | P10636 | 1/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.65 |
| ▸ | USP2 | O75604 | 1/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.64 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.64 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.64 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20258825 | 0.89 | ALDH1A1 (0.71) | ALDH1A1CYP2C19CYP1A2TSHRHPGD | |
| SCHEMBL20258782 | 0.89 | ALDH1A1 (0.71) | ALDH1A1CYP2C19CYP1A2TSHRHPGD | |
| SCHEMBL21766087 | 0.86 | PKM (0.78) | PKMTP53KMT2APLA2G1BATG4B | |
| SCHEMBL21765928 | 0.79 | TP53 (0.82) | ALDH1A1CYP2C19LMNAPKMTP53 | |
| SCHEMBL21765932 | 0.79 | GAA (0.53) | CYP2C19TSHRLMNAPKMPOLB | |
| SCHEMBL5243818 | 0.79 | MEN1 (0.67) | ALDH1A1LMNAPKMTP53POLB | |
| SCHEMBL21800686 | 0.78 | ALDH1A1 (0.71) | ALDH1A1CYP2C19CYP1A2TSHRHPGD | |
| SCHEMBL20258778 | 0.78 | PKM (0.69) | ALDH1A1LMNAPKMTP53PLA2G1B | |
| SCHEMBL21800651 | 0.77 | ALDH1A1 (0.71) | ALDH1A1CYP2C19CYP1A2TSHRHPGD | |
| SCHEMBL21765931 | 0.77 | SLC13A5 (0.82) | ALDH1A1TP53POLBMAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10793522-B2 | Sulfonamides as inhibitors of the uptake of extracellular citrate | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2020-10-06 | — | — | US | disclosed |
| US-20200062708-A1 | SULFONAMIDES AS INHIBITORS OF THE UPTAKE OF EXTRACELLULAR CITRATE | BOEHRINGER INGELHEIM PHARMA GBMH & CO KG (DE) | 2020-02-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200062708-A1 | SULFONAMIDES AS INHIBITORS OF THE UPTAKE OF EXTRACELLULAR CITRATE | CS, GLS, GLS2 | ALDH1A1 732/4885CYP2C19 978/4885CYP1A2 843/4885 |
| US-10793522-B2 | Sulfonamides as inhibitors of the uptake of extracellular citrate | CS, GLS, GLS2 | ALDH1A1 732/4885CYP2C19 978/4885CYP1A2 843/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.