Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CTSB | P07858 | 2/20 | 0.33 |
| ▸ | DPP4 | P27487 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | CTSL | P07711 | 1/20 | 0.33 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.33 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | CTSS | P25774 | 1/20 | 0.32 |
| ▸ | CTSK | P43235 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23547584 | 0.91 | MEN1 (0.39) | P2RX7LMNAHSD17B10MEN1KMT2A | |
| SCHEMBL23052290 | 0.76 | LMNA (0.46) | LMNAMEN1KMT2AMTNR1AMTNR1B | |
| SCHEMBL15869712 | 0.74 | LMNA (0.45) | P2RX7LMNAMEN1KMT2A | |
| SCHEMBL19151155 | 0.72 | LMNA (0.42) | P2RX7LMNAMEN1KMT2AMTNR1A | |
| SCHEMBL16790608 | 0.72 | KCNH2 (0.36) | P2RX7NPSR1KCNH2ALDH1A1KDM4E | |
| SCHEMBL31119581 | 0.71 | P2RX7 (0.38) | P2RX7LMNAHSD17B10DPP4ALDH1A1 | |
| SCHEMBL23892031 | 0.71 | SLC6A4 (0.37) | P2RX7ALDH1A1 | |
| SCHEMBL9392412 | 0.71 | P2RX7 (0.36) | P2RX7LMNAHSD17B10MEN1KMT2A | |
| SCHEMBL9392418 | 0.71 | P2RX7 (0.36) | P2RX7LMNAHSD17B10MEN1KMT2A | |
| Acetic Acid SCHEMBL9843655 | 0.71 | ALDH1A1 (0.37) | P2RX7LMNADPP4ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3402785-B1 | 3-(CARBOXYMETHYL)-8-AMINO-2-OXO-1,3-DIAZA-SPIRO-[4.5]-DECANE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2020-02-26 | — | — | EP | disclosed |