SCHEMBL21767732

SCHEMBL21767732

Oc1cccc2ccc(-c3ccc4cccc(O)c4n3)nc12

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
METAP2 P50579 2/20 0.63
PLAU P00749 1/20 0.63
NCF1 P14598 1/20 0.63
ALOX12 P18054 3/20 0.61
ALDH1A1 P00352 2/20 0.61
CYP1A2 P05177 1/20 0.61
CYP3A4 P08684 1/20 0.61
CYP2C9 P11712 1/20 0.61
HPGD P15428 1/20 0.61
CYP2C19 P33261 1/20 0.61
HIF1A Q16665 1/20 0.61
HSD17B10 Q99714 1/20 0.61
KDM4E B2RXH2 5/20 0.57
KMT2A Q03164 5/20 0.57
SOS2 Q07890 1/20 0.57
PDE4D Q08499 2/20 0.56
TSHR P16473 2/20 0.56
MMP2 P08253 1/20 0.56
CHRM1 P11229 1/20 0.56
COMT P21964 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19603066 0.96 METAP2 (0.59) METAP2PLAUNCF1ALOX12ALDH1A1
SCHEMBL8344723 0.87 METAP2 (0.70) METAP2PLAUNCF1ALOX12ALDH1A1
SCHEMBL564494 0.86 PARP1 (0.58) METAP2PLAUNCF1ALOX12ALDH1A1
SCHEMBL29729655 0.86 PARP1 (0.58) METAP2PLAUNCF1ALOX12ALDH1A1
SCHEMBL2037595 0.86 METAP2 (0.53) METAP2PLAUNCF1ALOX12ALDH1A1
SCHEMBL6051223 0.85 KDM4E (0.57) METAP2PLAUNCF1ALOX12ALDH1A1
SCHEMBL6431677 0.84 PARP1 (0.57) METAP2PLAUNCF1ALOX12ALDH1A1
SCHEMBL29040616 0.84 PARP1 (0.57) METAP2PLAUNCF1ALOX12ALDH1A1
SCHEMBL29040612 0.84 PARP1 (0.57) METAP2PLAUNCF1ALOX12ALDH1A1
SCHEMBL30457867 0.84 PARP1 (0.57) METAP2PLAUNCF1ALOX12ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3786151-B1 METHOD FOR PRODUCING AMIDE COMPOUND CHUBU UNIV EDUCATIONAL FOUNDATION (JP) 2023-06-07 EP disclosed
CN-112020492-B Method for producing amide compound 学校法人中部大学 2023-05-05 CN disclosed
US-11512108-B2 Method for producing amide compound CHUBU UNIVERSITY EDUCATIONAL FOUNDATION (JP) 2022-11-29 US disclosed
US-11370747-B2 Method for producing amide compound CHUBU UNIVERSITY EDUCATIONAL FOUNDATION (JP) 2022-06-28 US disclosed
US-11370747-B2 Method for producing amide compound CHUBU UNIVERSITY EDUCATIONAL FOUNDATION (JP) 2022-06-28 US disclosed
US-11168249-B1 Luminescent polydentate polycyclic compounds for metal ions ZAVALETA FERNANDEZ DE CORDOVA ANDRES (US) 2021-11-09 US disclosed
US-20210147473-A1 METHOD FOR PRODUCING AMIDE COMPOUND CHUBU UNIVERSITY EDUCATIONAL FOUNDATION (JP) 2021-05-20 US disclosed
EP-3786151-A1 METHOD FOR PRODUCING AMIDE COMPOUND Chubu University Educational Foundation (JP) 2021-03-03 EP disclosed
US-20200131117-A1 METHOD FOR PRODUCING AMIDE COMPOUND CHUBU UNIVERSITY EDUCATIONAL FOUNDATION (JP) 2020-04-30 US disclosed
US-20200131117-A1 METHOD FOR PRODUCING AMIDE COMPOUND CHUBU UNIVERSITY EDUCATIONAL FOUNDATION (JP) 2020-04-30 US disclosed
EP-3617185-A1 METHOD FOR PRODUCING AMIDE COMPOUND Chubu University Educational Foundation (JP) 2020-03-04 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11168249-B1 Luminescent polydentate polycyclic compounds for metal ions PCBP1, CACYBP, CA9 METAP2 3548/4885PLAU 4474/4885NCF1 2436/4885
US-11512108-B2 Method for producing amide compound BCAT2, ASNS, VIP METAP2 393/4885PLAU 2475/4885NCF1 1788/4885
US-11370747-B2 Method for producing amide compound NAAA, ASNS, GLUL METAP2 1371/4885PLAU 3491/4885NCF1 2230/4885
US-20210147473-A1 METHOD FOR PRODUCING AMIDE COMPOUND ASNS, VIP, BCAT2 METAP2 384/4885PLAU 2453/4885NCF1 1637/4885
US-20200131117-A1 METHOD FOR PRODUCING AMIDE COMPOUND NAAA, ASNS, GLUL METAP2 1371/4885PLAU 3491/4885NCF1 2230/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.