Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK4 | Q16654 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | NAMPT | P43490 | 2/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.43 |
| ▸ | ABL2 | P42684 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.42 |
| ▸ | MGAT2 | Q10469 | 1/20 | 0.42 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.42 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.41 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 3/20 | 0.41 |
| ▸ | GRM1 | Q13255 | 3/20 | 0.41 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29941117 | 1.00 | PDK4 (0.47) | PDK4MEN1KMT2ANAMPTABL1 | |
| SCHEMBL21361618 | 0.88 | MGAT2 (0.44) | PDK4MEN1KMT2AABL1EGFR | |
| SCHEMBL30952437 | 0.88 | MGAT2 (0.44) | PDK4MEN1KMT2AABL1EGFR | |
| SCHEMBL6848748 | 0.88 | PDK4 (0.55) | PDK4MEN1KMT2ANAMPTGRM5 | |
| SCHEMBL29914770 | 0.88 | PDK4 (0.55) | PDK4MEN1KMT2ANAMPTGRM5 | |
| SCHEMBL21381680 | 0.87 | PDK4 (0.44) | PDK4NAMPTGRM5GRM1USP30 | |
| SCHEMBL30149826 | 0.87 | PDK4 (0.44) | PDK4NAMPTGRM5GRM1USP30 | |
| SCHEMBL22619074 | 0.85 | PDK4 (0.48) | PDK4NAMPTABL1EGFRSRC | |
| SCHEMBL23510810 | 0.84 | PDK4 (0.47) | PDK4NAMPTGRM5GRM1USP30 | |
| SCHEMBL3648168 | 0.84 | GRM5 (0.53) | PDK4NAMPTMKNK1GRM5GRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110573512-B | Heterocyclic compounds | 武田药品工业株式会社 | 2022-09-06 | — | — | CN | disclosed |
| US-10919891-B2 | Heterocyclic compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2021-02-16 | — | — | US | disclosed |
| US-10875862-B2 | — | — | 2020-12-29 | — | — | US | disclosed |
| US-20200131174-A1 | HETEROCYCLIC COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2020-04-30 | — | — | US | disclosed |
| EP-3617209-A1 | HETEROCYCLIC COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2020-03-04 | — | — | EP | disclosed |
| CN-110573512-A | Heterocyclic compounds | 武田药品工业株式会社 | 2019-12-13 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10919891-B2 | Heterocyclic compound | CASR, AGTR2, AGTR1 | PDK4 4139/4885MEN1 1763/4885KMT2A 2678/4885 |
| US-20200131174-A1 | HETEROCYCLIC COMPOUND | CASR, AGTR2, AGTR1 | PDK4 4139/4885MEN1 1763/4885KMT2A 2678/4885 |
| US-10875862-B2 | — | CASR, AGTR2, AGTR1 | PDK4 4431/4885MEN1 2648/4885KMT2A 3217/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.