Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | ABL1 | P00519 | 7/20 | 0.44 |
| ▸ | BCR | P11274 | 7/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NPY5R | Q15761 | 3/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26337498 | 0.81 | GBA1 (0.42) | MAPK1ALDH1A1TSHRHSD17B10L3MBTL1 | |
| SCHEMBL19105595 | 0.76 | MAPK1 (0.37) | MAPK1ALDH1A1TSHRHSD17B10L3MBTL1 | |
| SCHEMBL25559304 | 0.76 | MEN1 (0.46) | MAPK1ALDH1A1TSHRHSD17B10L3MBTL1 | |
| SCHEMBL21780697 | 0.75 | MEN1 (0.38) | MAPK1HSD17B10L3MBTL1MEN1KMT2A | |
| SCHEMBL26629817 | 0.71 | OPRK1 (0.34) | MAPK1ALDH1A1TSHRABL1BCR | |
| SCHEMBL29732880 | 0.70 | ALDH1A1 (0.51) | MAPK1ALDH1A1TSHRABL1BCR | |
| SCHEMBL17703487 | 0.70 | OPRK1 (0.64) | MAPK1ALDH1A1TSHRHSD17B10OPRK1 | |
| SCHEMBL26121984 | 0.69 | TSHR (0.42) | MAPK1ALDH1A1TSHRHSD17B10MEN1 | |
| SCHEMBL30599902 | 0.69 | TSHR (0.42) | MAPK1ALDH1A1TSHRHSD17B10MEN1 | |
| SCHEMBL22229900 | 0.69 | ALDH1A1 (0.51) | MAPK1ALDH1A1TSHRHSD17B10L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230303573-A1 | 3-((Hetero-)Aryl)-8-Amino-2-Oxo-1,3-Diaza-Spiro-[4.5]-Decane Derivatives | Grünenthal GmbH (DE) | 2023-09-28 | — | — | US | disclosed |
| EP-3722284-A1 | 3-((HETERO-)ARYL)-8-AMINO-2-OXO-1,3-DIAZA-SPIRO-[4.5]-DECANE DERIVATIVES | Grünenthal GmbH (DE) | 2020-10-14 | — | — | EP | disclosed |
| EP-3402781-B1 | 3-((HETERO-)ARYL)-8-AMINO-2-OXO-1,3-DIAZA-SPIRO-[4.5]-DECANE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2020-03-04 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230303573-A1 | 3-((Hetero-)Aryl)-8-Amino-2-Oxo-1,3-Diaza-Spiro-[4.5]-Decane Derivatives | OPRK1, OPRD1, OPRL1 | MAPK1 2996/4885ALDH1A1 337/4885TSHR 2261/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.