SCHEMBL2176947

SCHEMBL2176947

O=[PH](O)OCCc1ccc(S(=O)(=O)O)cc1.[Zr]

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.41
ALDH1A1 P00352 1/20 0.41
NT5E P21589 1/20 0.41
LMNA P02545 1/20 0.38
CA2 P00918 13/20 0.37
CA1 P00915 11/20 0.37
CA12 O43570 3/20 0.37
CA7 P43166 3/20 0.37
CA9 Q16790 3/20 0.37
CA4 P22748 2/20 0.37
CA6 P23280 2/20 0.37
CA5A P35218 2/20 0.37
CA14 Q9ULX7 2/20 0.37
CA5B Q9Y2D0 2/20 0.37
F2 P00734 2/20 0.36
TMPRSS4 Q9NRS4 2/20 0.36
TP53 P04637 1/20 0.36
CYP1A2 P05177 1/20 0.36
CYP2D6 P10635 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2173061 0.86 TSHR (0.44) TSHRALDH1A1NT5ELMNACA2
SCHEMBL437757 0.77 ESR1 (0.50) ALDH1A1CA2CA1CA12CA7
SCHEMBL11583429 0.75 LMNA (0.56) TSHRALDH1A1NT5ELMNACA2
SCHEMBL22973728 0.75 CES2 (0.36) TSHRALDH1A1CYP2D6
SCHEMBL13284437 0.75 CYP1A2 (0.47) CYP1A2SMN1; SMN2TDP1
SCHEMBL27190586 0.75 TAAR1 (0.47)
SCHEMBL11396462 0.75 LMNA (0.43) TSHRALDH1A1NT5ELMNACA2
SCHEMBL2817046 0.74 TDP1 (0.47) TSHRALDH1A1LMNACA2CA1
SCHEMBL1806675 0.72 LMNA (0.48) TSHRALDH1A1NT5ELMNACA2
SCHEMBL1806678 0.72 CA2 (0.67) TSHRALDH1A1NT5ELMNACA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7973109-B2 Crosslinked type layered metal phosphonate compound, production process therefor, non-crosslinked type layered metal phosphonate compound, production process therefor, as well as stock solution KABUSHIKI KAISHA TOYOTA CHUO KENKYUSHO (JP) 2011-07-05 US disclosed
US-20090093607-A1 Crosslinked type layered metal phosphonate compound, production process therefor, non-crosslinked type layered metal phosphonate compound, production process therefor, as well as stock solution KABUSHIKI KAISHA TOYOTA CHUO KENKYUSHO (JP) 2009-04-09 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090093607-A1 Crosslinked type layered metal phosphonate compound, production process therefor, non-crosslinked type layered metal phosphonate compound, production process therefor, as well as stock solution WEE1, WEE2, PPIP5K2 TSHR 4495/4885ALDH1A1 3622/4885NT5E 2489/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.