Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.40 |
| ▸ | CYSLTR2 | Q9NS75 | 5/20 | 0.36 |
| ▸ | CYSLTR1 | Q9Y271 | 5/20 | 0.36 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.36 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.36 |
| ▸ | ITGA2 | P17301 | 1/20 | 0.36 |
| ▸ | SDCBP | O00560 | 1/20 | 0.36 |
| ▸ | SDC2 | P34741 | 1/20 | 0.36 |
| ▸ | PLK1 | P53350 | 10/20 | 0.35 |
| ▸ | PLK3 | Q9H4B4 | 5/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2177305 | 1.00 | MAP3K5 (0.40) | MAP3K5CYSLTR2CYSLTR1ITGB3ITGA2B | |
| SCHEMBL2283333 | 0.89 | SDCBP (0.36) | MAP3K5SDCBPSDC2 | |
| SCHEMBL2178926 | 0.89 | NPC1 (0.38) | MAP3K5ITGB3ITGA2BITGA2SDCBP | |
| SCHEMBL2178932 | 0.89 | NPC1 (0.38) | MAP3K5ITGB3ITGA2BITGA2SDCBP | |
| SCHEMBL2178354 | 0.88 | GCK (0.38) | MAP3K5ITGB3ITGA2BITGA2SDCBP | |
| SCHEMBL2181260 | 0.87 | TRPV1 (0.42) | ITGB3ITGA2BITGA2PLK1TRPV1 | |
| SCHEMBL13719176 | 0.87 | TRPV1 (0.42) | ITGB3ITGA2BITGA2PLK1TRPV1 | |
| SCHEMBL2179566 | 0.86 | TRPV1 (0.44) | ITGB3ITGA2BITGA2SDCBPSDC2 | |
| SCHEMBL2179559 | 0.86 | TRPV1 (0.44) | ITGB3ITGA2BITGA2SDCBPSDC2 | |
| SCHEMBL2178885 | 0.86 | MAP3K5 (0.42) | MAP3K5ITGB3ITGA2BITGA2SDCBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8748426-B2 | Inhibitors of diacylglycerol acyl transferase | Piramal Enterprises Limited (IN) | 2014-06-10 | — | — | US | claimed |
| US-20120289505-A1 | INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE | Piramal Enterprises Limited (IN) | 2012-11-15 | — | — | US | claimed |
| EP-2519500-A1 | INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE | Piramal Healthcare Ltd. (IN) | 2012-11-07 | — | — | EP | claimed |
| WO-2011080718-A1 | INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE | PIRAMAL LIFE SCIENCES LIMITED (IN) | 2011-07-07 | — | — | WO | claimed |
| US-8748426-B2 | Inhibitors of diacylglycerol acyl transferase | Piramal Enterprises Limited (IN) | 2014-06-10 | — | — | US | disclosed |
| US-20120289505-A1 | INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE | Piramal Enterprises Limited (IN) | 2012-11-15 | — | — | US | disclosed |
| EP-2519500-A1 | INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE | Piramal Healthcare Ltd. (IN) | 2012-11-07 | — | — | EP | disclosed |
| WO-2011080718-A1 | INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE | PIRAMAL LIFE SCIENCES LIMITED (IN) | 2011-07-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120289505-A1 | INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE | DGAT1, DGAT2, LCAT | MAP3K5 2168/4885CYSLTR2 1676/4885CYSLTR1 1806/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.