SCHEMBL217735

SCHEMBL217735

O=P(Cl)(Cl)Cl.c1ccc(CCc2ccccc2)cc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOA P21397 2/20 0.50
MAOB P27338 2/20 0.50
TSHR P16473 1/20 0.50
FFAR1 O14842 1/20 0.50
ALDH1A1 P00352 1/20 0.50
HPGD P15428 1/20 0.50
ALOX15 P16050 1/20 0.50
ALOX12 P18054 1/20 0.50
CASP1 P29466 1/20 0.50
HSD17B10 Q99714 1/20 0.50
HDAC1 Q13547 1/20 0.48
KEAP1 Q14145 1/20 0.48
TDP1 Q9NUW8 2/20 0.48
CYP2A6 P11509 1/20 0.48
HTR2A P28223 1/20 0.48
SMN1; SMN2 Q16637 1/20 0.48
TAAR1 Q96RJ0 1/20 0.48
LOXL2 Q9Y4K0 1/20 0.48
ANPEP P15144 2/20 0.47
ERAP1 Q9NZ08 2/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Phosphoric Acid SCHEMBL412030 0.83 TSHR (0.61) MAOAMAOBTSHRFFAR1HDAC1
SCHEMBL7265672 0.82 TSHR (0.55) TSHRALDH1A1HPGDALOX15ALOX12
SCHEMBL6824408 0.82 TSHR (0.55) TSHRALDH1A1HPGDALOX15ALOX12
Benzene SCHEMBL3440179 0.82 ALDH1A1 (0.69) MAOAMAOBFFAR1ALDH1A1HPGD
SCHEMBL62125 0.82 ALDH1A1 (0.69) MAOAMAOBFFAR1ALDH1A1HPGD
SCHEMBL9741303 0.82 ALDH1A1 (0.69) MAOAMAOBFFAR1ALDH1A1HPGD
SCHEMBL1041355 0.79 ALDH1A1 (0.58) MAOAMAOBFFAR1ALDH1A1HPGD
SCHEMBL7136305 0.79 ALDH1A1 (0.58) MAOAMAOBFFAR1ALDH1A1HPGD
SCHEMBL8371905 0.79 TSHR (0.57) TSHRFFAR1HPGDHDAC1KEAP1
SCHEMBL10453073 0.79 TSHR (0.52) MAOAMAOBTSHRHDAC1HTR2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 71 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119463391-A High-strength flame-retardant plastic-wood board and manufacturing process thereof 美新科技股份有限公司 2025-02-18 CN claimed
CN-109384959-B Preparation method of phosphorus-nitrogen high-load hydrotalcite flame retardant 台州职业技术学院 2020-06-09 CN claimed
CN-119463391-A High-strength flame-retardant plastic-wood board and manufacturing process thereof 美新科技股份有限公司 2025-02-18 CN disclosed
US-20240279220-A1 INDOLE COMPOUNDS AND METHODS OF USE SIONNA THERAPEUTICS INC. 2024-08-22 US disclosed
EP-4396179-A1 INDOLE COMPOUNDS AND METHODS OF USE GENZYME CORPORATION (US) 2024-07-10 EP disclosed
WO-2023034992-A1 INDOLE COMPOUNDS AND METHODS OF USE GENZYME CORPORATION (US) 2023-03-09 WO disclosed
CN-112500441-A Preparation process of high-purity glycosyl phosphate 上海彩迩文生化科技有限公司 2021-03-16 CN disclosed
CN-106349217-B Serine/threonine kinase inhibitors 阵列生物制药公司 2020-08-28 CN disclosed
CN-109384959-B Preparation method of phosphorus-nitrogen high-load hydrotalcite flame retardant 台州职业技术学院 2020-06-09 CN disclosed
EP-2564834-A2 Compounds for Proteasome Enzyme Inhibition Onyx Therapeutics, Inc. (US) 2013-03-06 EP disclosed
US-20120101025-A1 Compounds For Enzyme Inhibition ONYX THERAPEUTICS, INC. (US) 2012-04-26 US disclosed
US-5614550-A ANTICHOLESTEROL AGENTS OR ARTERIOSCLEROSIS AGENTS FOR HUMANS SANKYO COMPANY, LIMITED (JP) 1997-03-25 US disclosed
US-5534529-A Substituted aromatic amides and ureas derivatives having anti-hypercholesteremic activity, their preparation and their therapeutic uses SANKYO COMPANY, LIMITED (JP) 1996-07-09 US disclosed
EP-0632036-A2 Amide and urea derivatives having anti-hypercholesteremic activity, their preparation and their therapeutic uses SANKYO COMPANY LIMITED (JP) 1995-01-04 EP disclosed
CN-1024668-C Preparation method of 2- (2-isoxazolidinyl) -2-tetrahydrofuran carboxylic acid derivative TAKEDA CHEMICAL INDUSTRIES LTD (JP) 1994-05-25 CN disclosed
US-4788215-A TREATMENT OF HYPERTHYROIDISM MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 1988-11-29 US disclosed
EP-0278501-A2 Nucleotide analogs, their production and use Takeda Chemical Industries, Ltd. (JP) 1988-08-17 EP disclosed
US-4713465-A Flavanone intermediates for halogenohydroxyflavones MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 1987-12-15 US disclosed
CN-85109633-A Process for the preparation of antibiotic derivatives 1987-01-07 CN disclosed
US-4165312-A TRYPTOPHANE-ALANINE-GLYCINE OR ALANINE-GLYCINE OR ALANINE-ASPARTIC ACID-ALANINE-SERINE(PHOSPHATE)-GLYCINE OR ALANINE-GLUTAMIC ACID, SLEEP INDUCERS HOFFMANN-LA ROCHE INC. (US) 1979-08-21 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240279220-A1 INDOLE COMPOUNDS AND METHODS OF USE CFTR, INMT, IDO1 MAOA 139/4885MAOB 103/4885TSHR 2973/4885
US-20120101025-A1 Compounds For Enzyme Inhibition ANPEP, DNPEP, CPN1 MAOA 546/4885MAOB 690/4885TSHR 2765/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.