Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 12/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | PDE2A | O00408 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28590955 | 0.87 | BTK (0.43) | BTKMEN1KMT2AKCNH2POLB | |
| SCHEMBL28590953 | 0.81 | KDM4C (0.40) | BTK | |
| SCHEMBL23362527 | 0.75 | PRKCI (0.50) | BTK | |
| SCHEMBL23363265 | 0.75 | KDM4C (0.56) | BTKLMNA | |
| SCHEMBL23363039 | 0.74 | CYP11B2 (0.46) | BTKPDE2A | |
| SCHEMBL21791249 | 0.72 | BTK (0.46) | BTKKCNH2 | |
| SCHEMBL23363241 | 0.72 | FFAR1 (0.47) | BTKMEN1KMT2AMAPTLMNA | |
| SCHEMBL23363421 | 0.71 | TAS1R3 (0.46) | MEN1KMT2APDE2ALMNA | |
| SCHEMBL20533091 | 0.71 | BTK (0.42) | BTK | |
| SCHEMBL20533090 | 0.71 | BTK (0.42) | BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3843847-A1 | FUSED IMIDAZOPYRIDINES AS REVERSIBLE INHIBITORS OF BRUTON'S TYROSINE KINASE (BTK) | Merck Patent GmbH (DE) | 2021-07-07 | — | — | EP | disclosed |
| WO-2020043638-A1 | FUSED IMIDAZOPYRIDINES AS REVERSIBLE INHIBITORS OF BRUTON'S TYROSINE KINASE (BTK) | MERCK PATENT GMBH (DE) | 2020-03-05 | — | — | WO | disclosed |