Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 5/20 | 0.45 |
| ▸ | CTSS | P25774 | 4/20 | 0.45 |
| ▸ | AKT1 | P31749 | 2/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | ACE | P12821 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 2/20 | 0.40 |
| ▸ | CTSB | P07858 | 2/20 | 0.40 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.40 |
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.40 |
| ▸ | CTSL | P07711 | 1/20 | 0.40 |
| ▸ | PTGES | O14684 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2178104 | 0.95 | CTSK (0.46) | CTSKCTSSAKT1ATMACE | |
| SCHEMBL2821042 | 0.84 | CTSK (0.40) | CTSKCTSSATMACECTSB | |
| SCHEMBL28108976 | 0.82 | CTSK (0.62) | CTSKCTSSATMACECTSB | |
| SCHEMBL22042132 | 0.82 | CTSK (0.62) | CTSKCTSSATMACECTSB | |
| SCHEMBL27730329 | 0.82 | CTSK (0.62) | CTSKCTSSATMACECTSB | |
| SCHEMBL2818140 | 0.81 | L3MBTL1 (0.50) | CTSKCTSSPPARGPPARA | |
| SCHEMBL2177713 | 0.79 | BACE1 (0.44) | CTSKCTSSAKT1BACE1CTSB | |
| SCHEMBL2754724 | 0.78 | CTSK (0.55) | CTSKCTSSATMACECTSB | |
| SCHEMBL15789261 | 0.76 | NR1H4 (0.48) | NR1H4PPARA | |
| SCHEMBL15789270 | 0.76 | NR1H4 (0.51) | NR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2340242-A2 | COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | Acucela, Inc. (US) | 2011-07-06 | — | — | EP | disclosed |
| WO-2010048332-A2 | COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | ACUCELA, INC. (US) | 2010-04-29 | — | — | WO | disclosed |