Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSPB1 | P04792 | 5/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.39 |
| ▸ | MET | P08581 | 5/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | PYGL | P06737 | 1/20 | 0.36 |
| ▸ | PYGM | P11217 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | AXL | P30530 | 5/20 | 0.34 |
| ▸ | TYRO3 | Q06418 | 5/20 | 0.34 |
| ▸ | MERTK | Q12866 | 5/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30310263 | 1.00 | HSPB1 (0.44) | HSPB1MAPTALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL30310264 | 1.00 | HSPB1 (0.44) | HSPB1MAPTALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL30310259 | 0.82 | PDGFRA (0.41) | HSPB1MAPTALDH1A1MAPK1POLB | |
| SCHEMBL26084094 | 0.82 | PDGFRA (0.41) | HSPB1MAPTALDH1A1MAPK1POLB | |
| SCHEMBL4814859 | 0.82 | TRPA1 (0.47) | HSPB1MAPTALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL29631602 | 0.82 | TRPA1 (0.47) | HSPB1MAPTALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL3095571 | 0.80 | ROCK2 (0.41) | METAXLTYRO3MERTKROCK2 | |
| SCHEMBL23081494 | 0.78 | HSPB1 (0.44) | HSPB1MAPTALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL29814379 | 0.78 | HSPB1 (0.44) | HSPB1MAPTALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL30310247 | 0.77 | FLT3 (0.48) | HSPB1MAPTALDH1A1MAPK1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240174666-A1 | PYRAZOLO[3,4-b]PYRIDINE COMPOUNDS AS INHIBITORS OF TAM AND MET KINASES | ARRAY BIOPHARMA INC. (US) | 2024-05-30 | — | — | US | disclosed |
| EP-3843850-B1 | PYRAZOLO[3,4-B]PYRIDINE COMPOUNDS AS INHIBITORS OF TAM AND MET KINASES | ARRAY BIOPHARMA INC (US) | 2023-11-15 | — | — | EP | disclosed |
| US-11780835-B2 | Pyrazolo[3,4-b]pyridine compounds as inhibitors of TAM and MET kinases | ARRAY BIOPHARMA INC. (US) | 2023-10-10 | — | — | US | disclosed |
| CN-115850301-A | Pyrazolone compound and composition and application thereof | 中山医诺维申新药研发有限公司 | 2023-03-28 | — | — | CN | disclosed |
| WO-2023002360-A1 | SOLID FORMS AND FORMULATIONS OF AN INHIBITOR OF TAM AND C-MET KINASES | PFIZER INC. (US) | 2023-01-26 | — | — | WO | disclosed |
| US-20230011441-A1 | PYRAZOLO[3,4-b]PYRIDINE COMPOUNDS AS INHIBITORS OF TAM AND MET KINASES | ARRAY BIOPHARMA INC. (US) | 2023-01-12 | — | — | US | disclosed |
| EP-3843850-A1 | PYRAZOLO[3,4-B]PYRIDINE COMPOUNDS AS INHIBITORS OF TAM AND MET KINASES | Array BioPharma Inc. (US) | 2021-07-07 | — | — | EP | disclosed |
| CN-112930215-A | Pyrazolo [3, 4-b ] pyridine compounds as TAM and MET kinase inhibitors | 阿雷生物药品公司 | 2021-06-08 | — | — | CN | disclosed |
| US-20200079770-A1 | PYRAZOLO[3,4-b]PYRIDINE COMPOUNDS AS INHIBITORS OF TAM AND MET KINASES | ARRAY BIOPHARMA INC. | 2020-03-12 | — | — | US | disclosed |
| WO-2020047184-A1 | PYRAZOLO[3,4-b]PYRIDINE COMPOUNDS AS INHIBITORS OF TAM AND MET KINASES | ARRAY BIOPHARMA INC. (US) | 2020-03-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230011441-A1 | PYRAZOLO[3,4-b]PYRIDINE COMPOUNDS AS INHIBITORS OF TAM AND MET KINASES | RET, MERTK, MET | HSPB1 3198/4885MAPT 767/4885ALDH1A1 2121/4885 |
| US-20240174666-A1 | PYRAZOLO[3,4-b]PYRIDINE COMPOUNDS AS INHIBITORS OF TAM AND MET KINASES | RET, MERTK, MET | HSPB1 3256/4885MAPT 833/4885ALDH1A1 2323/4885 |
| US-20200079770-A1 | PYRAZOLO[3,4-b]PYRIDINE COMPOUNDS AS INHIBITORS OF TAM AND MET KINASES | RET, MERTK, MET | HSPB1 3256/4885MAPT 833/4885ALDH1A1 2323/4885 |
| US-11780835-B2 | Pyrazolo[3,4-b]pyridine compounds as inhibitors of TAM and MET kinases | RET, MERTK, MET | HSPB1 3198/4885MAPT 767/4885ALDH1A1 2121/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.