Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 2/20 | 0.60 |
| ▸ | MERTK | Q12866 | 2/20 | 0.60 |
| ▸ | L3MBTL3 | Q96JM7 | 12/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 10/20 | 0.59 |
| ▸ | ATR | Q13535 | 1/20 | 0.59 |
| ▸ | BMPR1B | O00238 | 2/20 | 0.57 |
| ▸ | BMPR1A | P36894 | 2/20 | 0.57 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.57 |
| ▸ | ACVRL1 | P37023 | 2/20 | 0.57 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.57 |
| ▸ | L3MBTL4 | Q8NA19 | 1/20 | 0.54 |
| ▸ | MBTD1 | Q05BQ5 | 2/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18612197 | 0.89 | MERTK (0.59) | AXLMERTKL3MBTL3L3MBTL1ATR | |
| SCHEMBL18615821 | 0.87 | MERTK (0.58) | AXLMERTKL3MBTL3L3MBTL1ATR | |
| SCHEMBL18612199 | 0.85 | L3MBTL3 (0.59) | AXLMERTKL3MBTL3L3MBTL1ATR | |
| SCHEMBL21779417 | 0.83 | MERTK (0.64) | AXLMERTKL3MBTL3L3MBTL1ATR | |
| SCHEMBL18611892 | 0.83 | MERTK (0.55) | AXLMERTKL3MBTL3L3MBTL1MBTD1 | |
| SCHEMBL18617157 | 0.82 | FYN (0.66) | AXLMERTKL3MBTL1ATRBMPR1B | |
| SCHEMBL18615511 | 0.80 | BMPR1B (0.62) | AXLMERTKL3MBTL3L3MBTL1BMPR1B | |
| SCHEMBL2750408 | 0.78 | ATR (0.57) | AXLMERTKL3MBTL3L3MBTL1ATR | |
| SCHEMBL30452813 | 0.78 | MET (0.58) | AXLMERTKL3MBTL3L3MBTL1ATR | |
| SCHEMBL488047 | 0.78 | MET (0.58) | AXLMERTKL3MBTL3L3MBTL1ATR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3344613-B1 | HETEROARYL COMPOUNDS AND THEIR USE AS THERAPEUTIC DRUGS | DONG A SOCIO HOLDINGS CO LTD (KR) | 2020-03-04 | — | — | EP | disclosed |